Synthesis and properties of amphiphilic star polysulfides

Lei Wang; Giona Kilcher; Nicola Tirelli

doi:10.1002/mabi.200700109

Synthesis and properties of amphiphilic star polysulfides

Lei Wang, Giona Kilcher, Nicola Tirelli

Research output: Contribution to journal › Article › peer-review

Abstract

We here present the synthesis and characterisation of linear and star-shaped amphiphilic block copolymers based on hydrophobic polysulfides (poly(propylene sulfide), PPS) and hydrophilic polyethers (poly(ethylene glycol), PEG). We also discuss the proof of the principle of their responsiveness to oxidising conditions. In a water environment, these polymers aggregate in the form of sub-micron carriers that, due to the sensitivity to oxidation reactions typical of PPS, can be used for responsive drug delivery. In this first study we have focused on the study of large aggregates, which do not apparently show dramatic differences in behaviour when polymer chains with different degrees of branching are studied. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	987-998
Number of pages	11
Journal	Macromolecular Bioscience
Volume	7
Issue number	8
DOIs	https://doi.org/10.1002/mabi.200700109
Publication status	Published - 7 Aug 2007

Keywords

Block copolymers
Responsive release
Self-assembly
Star polymers

Access to Document

10.1002/mabi.200700109

Cite this

@article{f46d15db39874afa92d21776d78512a5,

title = "Synthesis and properties of amphiphilic star polysulfides",

abstract = "We here present the synthesis and characterisation of linear and star-shaped amphiphilic block copolymers based on hydrophobic polysulfides (poly(propylene sulfide), PPS) and hydrophilic polyethers (poly(ethylene glycol), PEG). We also discuss the proof of the principle of their responsiveness to oxidising conditions. In a water environment, these polymers aggregate in the form of sub-micron carriers that, due to the sensitivity to oxidation reactions typical of PPS, can be used for responsive drug delivery. In this first study we have focused on the study of large aggregates, which do not apparently show dramatic differences in behaviour when polymer chains with different degrees of branching are studied. {\textcopyright} 2007 Wiley-VCH Verlag GmbH & Co. KGaA.",

keywords = "Block copolymers, Responsive release, Self-assembly, Star polymers",

author = "Lei Wang and Giona Kilcher and Nicola Tirelli",

year = "2007",

month = aug,

day = "7",

doi = "10.1002/mabi.200700109",

language = "English",

volume = "7",

pages = "987--998",

journal = "Macromolecular Bioscience",

issn = "1616-5195",

publisher = "John Wiley & Sons Ltd",

number = "8",

}

TY - JOUR

T1 - Synthesis and properties of amphiphilic star polysulfides

AU - Wang, Lei

AU - Kilcher, Giona

AU - Tirelli, Nicola

PY - 2007/8/7

Y1 - 2007/8/7

N2 - We here present the synthesis and characterisation of linear and star-shaped amphiphilic block copolymers based on hydrophobic polysulfides (poly(propylene sulfide), PPS) and hydrophilic polyethers (poly(ethylene glycol), PEG). We also discuss the proof of the principle of their responsiveness to oxidising conditions. In a water environment, these polymers aggregate in the form of sub-micron carriers that, due to the sensitivity to oxidation reactions typical of PPS, can be used for responsive drug delivery. In this first study we have focused on the study of large aggregates, which do not apparently show dramatic differences in behaviour when polymer chains with different degrees of branching are studied. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - We here present the synthesis and characterisation of linear and star-shaped amphiphilic block copolymers based on hydrophobic polysulfides (poly(propylene sulfide), PPS) and hydrophilic polyethers (poly(ethylene glycol), PEG). We also discuss the proof of the principle of their responsiveness to oxidising conditions. In a water environment, these polymers aggregate in the form of sub-micron carriers that, due to the sensitivity to oxidation reactions typical of PPS, can be used for responsive drug delivery. In this first study we have focused on the study of large aggregates, which do not apparently show dramatic differences in behaviour when polymer chains with different degrees of branching are studied. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

KW - Block copolymers

KW - Responsive release

KW - Self-assembly

KW - Star polymers

U2 - 10.1002/mabi.200700109

DO - 10.1002/mabi.200700109

M3 - Article

SN - 1616-5195

VL - 7

SP - 987

EP - 998

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

IS - 8

ER -

Synthesis and properties of amphiphilic star polysulfides

Abstract

Keywords

Access to Document

Fingerprint

Cite this