Synthesis and reactions of the pestalotiopsin skeleton

Thomas M. Baker, David J. Edmonds, Deborah Hamilton, Christopher J. O'Brien, David J. Procter

    Research output: Contribution to journalArticlepeer-review


    (Chemical Equation Presented) Family ties: The pestalotiopsin framework has been constructed by using a SmI2-mediated cyclization and a Nozaki-Hiyama-Kishi coupling to construct the four- and nine-membered rings of the target, respectively. The first synthetic entry into the previously unexplored taedolidol family of natural products has been achieved through a stereoselective, acid-mediated cyclization of the pestalotiopsin skeleton. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
    Original languageEnglish
    Pages (from-to)5631-5633
    Number of pages2
    JournalAngewandte Chemie - International Edition
    Issue number30
    Publication statusPublished - 14 Jul 2008


    • Natural products
    • Pestalotiopsins
    • Samarium
    • Taedolidols
    • Total synthesis


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