Synthesis and spectroscopic properties of a prototype single molecule dual imaging agent comprising a heterobimetallic rhenium-gadolinium complex

Thelma Koullourou; Louise S. Natrajan; Hiren Bhavsar; Simon J A Pope; Jianghua Feng; Johanna Narvainen; Rachel Shaw; Emma Scales; Risto Kauppinen; Alan M. Kenwright; Stephen Faulkner

doi:10.1021/ja710859p

Synthesis and spectroscopic properties of a prototype single molecule dual imaging agent comprising a heterobimetallic rhenium-gadolinium complex

Thelma Koullourou, Louise S. Natrajan, Hiren Bhavsar, Simon J A Pope, Jianghua Feng, Johanna Narvainen, Rachel Shaw, Emma Scales, Risto Kauppinen, Alan M. Kenwright, Stephen Faulkner

Research output: Contribution to journal › Article › peer-review

Abstract

A luminescent d-f hybrid containing a [Re(bpy)(Ar)(CO)3]+ chromophore and a gadolinium ion bound in a DO3A-derived binding pocket has been prepared. This complex combines long-lived luminescence from the 3MLCT state of the transition metal chromophore with high relaxivity, making it suitable for MRI imaging and luminescence imaging. The analogous complex containing ytterbium exhibits sensitized emission from both the ytterbium center and long-lived emission from the 3MLCT state. Copyright © 2008 American Chemical Society.

Original language	English
Pages (from-to)	2178-2179
Number of pages	1
Journal	Journal of the American Chemical Society
Volume	130
Issue number	7
DOIs	https://doi.org/10.1021/ja710859p
Publication status	Published - 20 Feb 2008

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10.1021/ja710859p

CCDC 685293: Experimental Crystal Structure Determination
Koullourou, T. (Contributor), Natrajan, L. (Contributor), Bhavsar, H. (Contributor), Pope, S. J. A. (Contributor), Feng, J. (Contributor), Närväinen, J. (Contributor), Shaw, R. (Contributor), Scales, E. (Contributor), Kauppinen, R. A. (Contributor), Kenwright, A. M. (Contributor) & Faulkner, S. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2008
DOI: 10.5517/ccr0372, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccr0372&sid=DataCite
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Koullourou, T., Natrajan, L. S., Bhavsar, H., Pope, S. J. A., Feng, J., Narvainen, J., Shaw, R., Scales, E., Kauppinen, R., Kenwright, A. M., & Faulkner, S. (2008). Synthesis and spectroscopic properties of a prototype single molecule dual imaging agent comprising a heterobimetallic rhenium-gadolinium complex. Journal of the American Chemical Society, 130(7), 2178-2179. https://doi.org/10.1021/ja710859p

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abstract = "A luminescent d-f hybrid containing a [Re(bpy)(Ar)(CO)3]+ chromophore and a gadolinium ion bound in a DO3A-derived binding pocket has been prepared. This complex combines long-lived luminescence from the 3MLCT state of the transition metal chromophore with high relaxivity, making it suitable for MRI imaging and luminescence imaging. The analogous complex containing ytterbium exhibits sensitized emission from both the ytterbium center and long-lived emission from the 3MLCT state. Copyright {\textcopyright} 2008 American Chemical Society.",

author = "Thelma Koullourou and Natrajan, {Louise S.} and Hiren Bhavsar and Pope, {Simon J A} and Jianghua Feng and Johanna Narvainen and Rachel Shaw and Emma Scales and Risto Kauppinen and Kenwright, {Alan M.} and Stephen Faulkner",

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Koullourou, T, Natrajan, LS, Bhavsar, H, Pope, SJA, Feng, J, Narvainen, J, Shaw, R, Scales, E, Kauppinen, R, Kenwright, AM & Faulkner, S 2008, 'Synthesis and spectroscopic properties of a prototype single molecule dual imaging agent comprising a heterobimetallic rhenium-gadolinium complex', Journal of the American Chemical Society, vol. 130, no. 7, pp. 2178-2179. https://doi.org/10.1021/ja710859p

TY - JOUR

T1 - Synthesis and spectroscopic properties of a prototype single molecule dual imaging agent comprising a heterobimetallic rhenium-gadolinium complex

AU - Koullourou, Thelma

AU - Natrajan, Louise S.

AU - Bhavsar, Hiren

AU - Pope, Simon J A

AU - Feng, Jianghua

AU - Narvainen, Johanna

AU - Shaw, Rachel

AU - Scales, Emma

AU - Kauppinen, Risto

AU - Kenwright, Alan M.

AU - Faulkner, Stephen

PY - 2008/2/20

Y1 - 2008/2/20

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AB - A luminescent d-f hybrid containing a [Re(bpy)(Ar)(CO)3]+ chromophore and a gadolinium ion bound in a DO3A-derived binding pocket has been prepared. This complex combines long-lived luminescence from the 3MLCT state of the transition metal chromophore with high relaxivity, making it suitable for MRI imaging and luminescence imaging. The analogous complex containing ytterbium exhibits sensitized emission from both the ytterbium center and long-lived emission from the 3MLCT state. Copyright © 2008 American Chemical Society.

U2 - 10.1021/ja710859p

DO - 10.1021/ja710859p

M3 - Article

SN - 0002-7863

VL - 130

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 7

ER -

Synthesis and spectroscopic properties of a prototype single molecule dual imaging agent comprising a heterobimetallic rhenium-gadolinium complex

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CCDC 685293: Experimental Crystal Structure Determination

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