Synthesis, degradation, and in vitro cell responses of sodium phosphate glasses for craniofacial bone repair

J. E. Gough, P. Christian, C. A. Scotchford, C. D. Rudd, I. A. Jones

    Research output: Contribution to journalArticlepeer-review


    Abstract: This report outlines the initial synthesis, degradation, and short-term biocompatibility of sodium phosphate glasses, for use in the drawing of fibers and manufacture of biodegradable composites. Biocompatibility studies were performed using a macrophage cell line and primary human craniofacial osteoblasts. Sodium hydrogen phosphate and sodium dihydrogen phosphate glass synthesized for less than 1 h, resulted in a higher degradation rate than glass synthesized for 3 h or more (0.015 mg cm-2 h-1). Glasses with high and low ratios of hydrogen phosphate to dihydrogen phosphate had very similar degradation rates. A condensation route for the formation of the glass should give rise to varying degradation rates with varying ratios of starting materials. It is suggested that the degradation rate of the glass is independent of the concentrations of the initial reagents and that ring-opening polymerization, which reaches an equilibrium state, occurs. Biocompatibility studies suggest minimal macrophage activation (low levels of peroxide and interleukin-1β release and rounded morphology) and high osteoblast biocompatibility. The ultimate aim of our studies is to produce a biocompatible soluble phosphate glass that can be drawn into fibers for incorporation into a polycaprolactone matrix for craniofacial bone repair. This report demonstrates the successful production of a soluble glass, which is biocompatible with regard to osteoblasts and macrophages. Recent data from our laboratory have demonstrated successful fiber drawing and production of a novel polycaprolactone. © 2001 John Wiley & Sons, Inc.
    Original languageEnglish
    Pages (from-to)481-489
    Number of pages8
    JournalJournal of Biomedical Materials Research
    Issue number3
    Publication statusPublished - 5 Mar 2002


    • Craniofacial bone repair
    • Degradable
    • Macrophage
    • Osteoblast
    • Sodium phosphate glass


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