Synthesis of 1,3-disubstituted azetidines via a tandem ring-opening ring-closing procedure

Andrea March-Cortijos; Timothy J. Snape; Nicholas J. Turner

doi:10.1055/s-0031-1291014

Synthesis of 1,3-disubstituted azetidines via a tandem ring-opening ring-closing procedure

Andrea March-Cortijos, Timothy J. Snape^*, Nicholas J. Turner

^*Corresponding author for this work

University of Central Lancashire

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of N-substituted symmetrical azetidines has been achieved in high yields via the reaction of primary amines undergoing an epoxide ring-opening reaction followed by an in situ ring-closing step.

Original language	English
Article number	ST-2012-D0041-L
Pages (from-to)	1511-1515
Number of pages	5
Journal	SYNLETT
Volume	23
Issue number	10
DOIs	https://doi.org/10.1055/s-0031-1291014
Publication status	Published - 30 May 2012

Keywords

azetidines
azo compounds
cyclization
tandem reaction
tertiary alcohols

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

Access to Document

10.1055/s-0031-1291014

Cite this

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title = "Synthesis of 1,3-disubstituted azetidines via a tandem ring-opening ring-closing procedure",

abstract = "The synthesis of N-substituted symmetrical azetidines has been achieved in high yields via the reaction of primary amines undergoing an epoxide ring-opening reaction followed by an in situ ring-closing step.",

keywords = "azetidines, azo compounds, cyclization, tandem reaction, tertiary alcohols",

author = "Andrea March-Cortijos and Snape, {Timothy J.} and Turner, {Nicholas J.}",

year = "2012",

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AU - March-Cortijos, Andrea

AU - Snape, Timothy J.

AU - Turner, Nicholas J.

PY - 2012/5/30

Y1 - 2012/5/30

N2 - The synthesis of N-substituted symmetrical azetidines has been achieved in high yields via the reaction of primary amines undergoing an epoxide ring-opening reaction followed by an in situ ring-closing step.

AB - The synthesis of N-substituted symmetrical azetidines has been achieved in high yields via the reaction of primary amines undergoing an epoxide ring-opening reaction followed by an in situ ring-closing step.

KW - azetidines

KW - azo compounds

KW - cyclization

KW - tandem reaction

KW - tertiary alcohols

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U2 - 10.1055/s-0031-1291014

DO - 10.1055/s-0031-1291014

M3 - Article

AN - SCOPUS:84861470665

SN - 0936-5214

VL - 23

SP - 1511

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JO - SYNLETT

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M1 - ST-2012-D0041-L

ER -

Synthesis of 1,3-disubstituted azetidines via a tandem ring-opening ring-closing procedure

Abstract

Keywords

Research Beacons, Institutes and Platforms

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CCDC 840439: Experimental Crystal Structure Determination

CCDC 840438: Experimental Crystal Structure Determination

Cite this

Synthesis of 1,3-disubstituted azetidines via a tandem ring-opening ring-closing procedure

Abstract

Keywords

Research Beacons, Institutes and Platforms

Access to Document

Other files and links

Fingerprint

Datasets

CCDC 840439: Experimental Crystal Structure Determination

CCDC 840438: Experimental Crystal Structure Determination

Cite this