Abstract
(3R*,4R*)-4-Acetylamino-3-(pent-3-oxy)cyclohex-1-ene-1-carboxylic acid and its (3S*,4R*)-isomer are synthesised in five steps from the Diels-Alder cycloadduct of (E)-1-acetoxy-3-methylbuta-1,3-diene and nitroethene; the former acid is a moderately potent inhibitor of influenza A sialidase. © 2001 Elsevier Science Ltd. All rights reserved.
Original language | English |
---|---|
Pages (from-to) | 7687-7690 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 42 |
Issue number | 43 |
DOIs | |
Publication status | Published - 22 Oct 2001 |
Keywords
- Antivirals
- Diels-Alder reactions
- Nitro compounds
- Oxidation (allylic)