Synthesis of 9-acridinyl sulfur derivatives: Sulfides, sulfoxides and sulfones. Comparison of their activity on tumour cells

Christiane Santelli-Rouvier; Jean Marc Barret; Christopher M. Farrell; Derek Sharples; Bridget T. Hill; Jacques Barbe

doi:10.1016/j.ejmech.2004.06.015

Synthesis of 9-acridinyl sulfur derivatives: Sulfides, sulfoxides and sulfones. Comparison of their activity on tumour cells

Christiane Santelli-Rouvier, Jean Marc Barret, Christopher M. Farrell, Derek Sharples, Bridget T. Hill, Jacques Barbe

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of several acridine thioethers is described. These compounds were oxidized to give new sulfoxides and sulfones. Among 23:compounds prepared, 19:were tested in vitro against the human cancer cell lines panel of NCI screening. Activity is increased 5-10:times from sulfides to sulfoxides. Among substituted groups in the side chain, sulfur mustard, epoxy sulfide and sulfoxide displayed the most interesting activity. © 2004 Elsevier SAS. All rights reserved.

Original language	English
Pages (from-to)	1029-1038
Number of pages	9
Journal	European Journal of Medicinal Chemistry
Volume	39
Issue number	12
DOIs	https://doi.org/10.1016/j.ejmech.2004.06.015
Publication status	Published - Dec 2004

Keywords

Acridine sulfides
Anticancer activity
DNA interaction
Sulfones
Sulfoxides

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejmech.2004.06.015

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@article{359bb911380641dea78881e11bcddbc7,

title = "Synthesis of 9-acridinyl sulfur derivatives: Sulfides, sulfoxides and sulfones. Comparison of their activity on tumour cells",

abstract = "The synthesis of several acridine thioethers is described. These compounds were oxidized to give new sulfoxides and sulfones. Among 23:compounds prepared, 19:were tested in vitro against the human cancer cell lines panel of NCI screening. Activity is increased 5-10:times from sulfides to sulfoxides. Among substituted groups in the side chain, sulfur mustard, epoxy sulfide and sulfoxide displayed the most interesting activity. {\textcopyright} 2004 Elsevier SAS. All rights reserved.",

keywords = "Acridine sulfides, Anticancer activity, DNA interaction, Sulfones, Sulfoxides",

author = "Christiane Santelli-Rouvier and Barret, {Jean Marc} and Farrell, {Christopher M.} and Derek Sharples and Hill, {Bridget T.} and Jacques Barbe",

year = "2004",

month = dec,

doi = "10.1016/j.ejmech.2004.06.015",

language = "English",

volume = "39",

pages = "1029--1038",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

number = "12",

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TY - JOUR

T1 - Synthesis of 9-acridinyl sulfur derivatives: Sulfides, sulfoxides and sulfones. Comparison of their activity on tumour cells

AU - Santelli-Rouvier, Christiane

AU - Barret, Jean Marc

AU - Farrell, Christopher M.

AU - Sharples, Derek

AU - Hill, Bridget T.

AU - Barbe, Jacques

PY - 2004/12

Y1 - 2004/12

N2 - The synthesis of several acridine thioethers is described. These compounds were oxidized to give new sulfoxides and sulfones. Among 23:compounds prepared, 19:were tested in vitro against the human cancer cell lines panel of NCI screening. Activity is increased 5-10:times from sulfides to sulfoxides. Among substituted groups in the side chain, sulfur mustard, epoxy sulfide and sulfoxide displayed the most interesting activity. © 2004 Elsevier SAS. All rights reserved.

AB - The synthesis of several acridine thioethers is described. These compounds were oxidized to give new sulfoxides and sulfones. Among 23:compounds prepared, 19:were tested in vitro against the human cancer cell lines panel of NCI screening. Activity is increased 5-10:times from sulfides to sulfoxides. Among substituted groups in the side chain, sulfur mustard, epoxy sulfide and sulfoxide displayed the most interesting activity. © 2004 Elsevier SAS. All rights reserved.

KW - Acridine sulfides

KW - Anticancer activity

KW - DNA interaction

KW - Sulfones

KW - Sulfoxides

U2 - 10.1016/j.ejmech.2004.06.015

DO - 10.1016/j.ejmech.2004.06.015

M3 - Article

SN - 0223-5234

VL - 39

SP - 1029

EP - 1038

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 12

ER -

Synthesis of 9-acridinyl sulfur derivatives: Sulfides, sulfoxides and sulfones. Comparison of their activity on tumour cells

Abstract

Keywords

UN SDGs

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