Synthesis of a C1-C9 fragment of rhizoxin

R. J. Davenport, A. C. Regan

    Research output: Contribution to journalArticlepeer-review


    A C1-C9 fragment of the antitumour macrolide rhizoxin has been synthesised. An Evans' asymmetric aldol reaction was used to set up the first two chiral centres, and an α,β-unsaturated δ-lactone was then formed on the acyclic system by an intramolecular Wadsworth-Emmons reaction. Stereoselective hydrogenation was used to set up the cis relative stereochemistry in the saturated δ-lactone ring. (C) 2000 Published by Elsevier Science Ltd.
    Original languageEnglish
    Pages (from-to)7619-7622
    Number of pages3
    JournalTetrahedron Letters
    Issue number40
    Publication statusPublished - 30 Sept 2000


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