Synthesis of a novel monomer “DDTU-IDI” for the development of low-shrinkage dental resin composites

Zixuan Zhou, Aihua Li, Ke Sun, Di Guo, Tingting Li, Jun Lu, Bruna s.h. Tonin, Zhou Ye, David c. Watts, Ting Wang, Jing Fu

Research output: Contribution to journalArticlepeer-review

4 Downloads (Pure)

Abstract

Objective
The current dental resin composites often suffer from polymerization shrinkage, which can lead to microleakage and potentially result in recurring tooth decay. This study presents the synthesis of a novel monomer, (3,9-diethyl-1,5,7,11-tetraoxaspiro[5,5]undecane-3,9-diyl)bis(methylene) bis((2-(3-(prop-1-en-2-yl)phenyl)propan-2-yl)carbamate) (DDTU-IDI), and evaluates its effect in the formulation of low-shrinkage dental resin composites.

Methods
DDTU-IDI was synthesized through a two-step reaction route, with the initial synthesis of the required raw material monomer 3,9-diethyl-3,9-dihydroxymethyl-1,5,7,11-tetraoxaspiro-[5,5] undecane (DDTU). The structures were confirmed using Fourier-transform infrared (FT-IR) spectroscopy and hydrogen nuclear magnetic resonance (1HNMR) spectroscopy. Subsequently, DDTU-IDI was incorporated into Bis-GMA-based composites at varying weight percentages (5, 10, 15, and 20 wt%). The polymerization reaction, degree of conversion, polymerization shrinkage, mechanical properties, physicochemical properties and biocompatibility of the low-shrinkage composites were thoroughly evaluated. Furthermore, the mechanical properties were assessed after a thermal cycling test with 10,000 cycles to determine the stability.

Results
The addition of DDTU-IDI at 10, 15, and 20 wt% significantly reduced the polymerization volumetric shrinkage of the experimental resin composites, without compromising the degree of conversion, mechanical and physicochemical properties. Remarkably, at a monomer content of 20 wt%, the polymerization shrinkage was reduced to 1.83 ± 0.53%. Composites containing 10, 15, and 20 wt% DDTU-IDI exhibited lower water sorption and higher contact angle. Following thermal cycling, the composites exhibited no significant decrease in mechanical properties, except for the flexural properties.

Significance. DDTU-IDI has favorable potential as a component which could produce volume expansion and increase rigidity in the development of low-shrinkage dental resin composites. The development of low-shrinkage composites containing DDTU-IDI appears to be a promising strategy for reducing polymerization shrinkage, thereby potentially enhancing the longevity of dental restorations.
Original languageEnglish
Pages (from-to)608-618
JournalDental Materials
Volume40
Issue number4
Early online date18 Feb 2024
DOIs
Publication statusPublished - 1 Apr 2024

Keywords

  • Polymerization shrinkage
  • Monomer
  • Resin composites
  • Physical properties
  • Thermocycling

Fingerprint

Dive into the research topics of 'Synthesis of a novel monomer “DDTU-IDI” for the development of low-shrinkage dental resin composites'. Together they form a unique fingerprint.

Cite this