Abstract
An efficient synthesis of a phosphinate analogue of the anti-tumour phosphate di-ester perifosine is described (6 steps and 50% overall yield). The two phosphorus-carbon bonds in the perifosine analogue were prepared by sequential double radical hydrophosphinylation processes. This is the first example of a phosphinate analogue of perifosine, designed to be resistant to hydrolysis by phospholipid-metabolizing enzymes. This journal is © The Royal Society of Chemistry.
Original language | English |
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Pages (from-to) | 119-129 |
Number of pages | 10 |
Journal | Organic and Biomolecular Chemistry |
Volume | 11 |
Issue number | 1 |
DOIs | |
Publication status | Published - 7 Jan 2013 |