Synthesis of a phosphinate analogue of the anti-tumour phosphate di-ester perifosine via sequential radical processes

Marios S. Markoulides, Andrew C. Regan

    Research output: Contribution to journalArticlepeer-review

    42 Downloads (Pure)

    Abstract

    An efficient synthesis of a phosphinate analogue of the anti-tumour phosphate di-ester perifosine is described (6 steps and 50% overall yield). The two phosphorus-carbon bonds in the perifosine analogue were prepared by sequential double radical hydrophosphinylation processes. This is the first example of a phosphinate analogue of perifosine, designed to be resistant to hydrolysis by phospholipid-metabolizing enzymes. This journal is © The Royal Society of Chemistry.
    Original languageEnglish
    Pages (from-to)119-129
    Number of pages10
    JournalOrganic and Biomolecular Chemistry
    Volume11
    Issue number1
    DOIs
    Publication statusPublished - 7 Jan 2013

    Fingerprint

    Dive into the research topics of 'Synthesis of a phosphinate analogue of the anti-tumour phosphate di-ester perifosine via sequential radical processes'. Together they form a unique fingerprint.

    Cite this