Synthesis of a tetrasaccharide related to the repeating unit of the O-antigen from Escherichia coli K-12

B. Roy; R.A. Field; B. Mukhopadhyay

doi:10.1016/j.carres.2009.09.026

Synthesis of a tetrasaccharide related to the repeating unit of the O-antigen from Escherichia coli K-12

B. Roy, R.A. Field, B. Mukhopadhyay

Manchester Institute of Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

Synthesis of a tetrasaccharide related to the repeating unit of the O-antigen from Escherichia coli K-12 is reported in the form of its octyl glycoside. Syntheses of the 1,2-cis glycosidic linkages have been accomplished by using NIS in conjunction with H(2)SO(4)-silica, and it was found to be stereoselective and productive. The synthesized tetrasaccharide will be utilized as the substrate for galactofuranosyltransferase, WbbI.

Original language	Undefined
Pages (from-to)	2311-2316
Number of pages	6
Journal	Carbohydrate Research
Volume	344
Issue number	17
DOIs	https://doi.org/10.1016/j.carres.2009.09.026
Publication status	Published - 2009

Keywords

Carbohydrate sequence
Escherichia coli K12
O antigens
Oligosaccharides

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

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10.1016/j.carres.2009.09.026

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abstract = "Synthesis of a tetrasaccharide related to the repeating unit of the O-antigen from Escherichia coli K-12 is reported in the form of its octyl glycoside. Syntheses of the 1,2-cis glycosidic linkages have been accomplished by using NIS in conjunction with H(2)SO(4)-silica, and it was found to be stereoselective and productive. The synthesized tetrasaccharide will be utilized as the substrate for galactofuranosyltransferase, WbbI.",

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AU - Roy, B.

AU - Field, R.A.

AU - Mukhopadhyay, B.

PY - 2009

Y1 - 2009

N2 - Synthesis of a tetrasaccharide related to the repeating unit of the O-antigen from Escherichia coli K-12 is reported in the form of its octyl glycoside. Syntheses of the 1,2-cis glycosidic linkages have been accomplished by using NIS in conjunction with H(2)SO(4)-silica, and it was found to be stereoselective and productive. The synthesized tetrasaccharide will be utilized as the substrate for galactofuranosyltransferase, WbbI.

AB - Synthesis of a tetrasaccharide related to the repeating unit of the O-antigen from Escherichia coli K-12 is reported in the form of its octyl glycoside. Syntheses of the 1,2-cis glycosidic linkages have been accomplished by using NIS in conjunction with H(2)SO(4)-silica, and it was found to be stereoselective and productive. The synthesized tetrasaccharide will be utilized as the substrate for galactofuranosyltransferase, WbbI.

KW - Carbohydrate sequence

KW - Escherichia coli K12

KW - O antigens

KW - Oligosaccharides

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U2 - 10.1016/j.carres.2009.09.026

DO - 10.1016/j.carres.2009.09.026

M3 - Article

SN - 0008-6215

VL - 344

SP - 2311

EP - 2316

JO - Carbohydrate Research

JF - Carbohydrate Research

IS - 17

ER -

Synthesis of a tetrasaccharide related to the repeating unit of the O-antigen from Escherichia coli K-12

Abstract

Keywords

Research Beacons, Institutes and Platforms

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