Synthesis of densely functionalised arenes using [2 + 2 + 2] cycloaddition reactions

Jonathan Clayden; Wesley J. Moran

doi:10.1039/b700353f

Synthesis of densely functionalised arenes using [2 + 2 + 2] cycloaddition reactions

Jonathan Clayden, Wesley J. Moran

Research output: Contribution to journal › Article › peer-review

Abstract

Rh(i)-catalysed [2 + 2 + 2] cycloaddition allows the synthesis of aryl ethers and diaryl methanes containing a high degree of steric hindrance from relatively simple diyne and alkyne precursors. The diarylmethanes made in this way show no evidence in their NMR spectra, however, of rotational restriction. This journal is © The Royal Society of Chemistry.

Original language	English
Pages (from-to)	1028-1030
Number of pages	2
Journal	Organic and Biomolecular Chemistry
Volume	5
Issue number	7
DOIs	https://doi.org/10.1039/b700353f
Publication status	Published - 2007

Keywords

SUBSTITUTED DIARYL ETHERS
DIHYDROFOLATE-REDUCTASE
ENANTIOSELECTIVE
SYNTHESIS
PNEUMOCYSTIS-CARINII
MYCOBACTERIUM-AVIUM
TOXOPLASMA-GONDII
CYCLOTRIMERIZATION
TRIMETHOPRIM
ATROPISOMERS
DERIVATIVES

Access to Document

10.1039/b700353f

Cite this

@article{7708c5695ede4c71a5d521732a5a8f3e,

title = "Synthesis of densely functionalised arenes using [2 + 2 + 2] cycloaddition reactions",

abstract = "Rh(i)-catalysed [2 + 2 + 2] cycloaddition allows the synthesis of aryl ethers and diaryl methanes containing a high degree of steric hindrance from relatively simple diyne and alkyne precursors. The diarylmethanes made in this way show no evidence in their NMR spectra, however, of rotational restriction. This journal is {\textcopyright} The Royal Society of Chemistry.",

keywords = "SUBSTITUTED DIARYL ETHERS, DIHYDROFOLATE-REDUCTASE, ENANTIOSELECTIVE, SYNTHESIS, PNEUMOCYSTIS-CARINII, MYCOBACTERIUM-AVIUM, TOXOPLASMA-GONDII, CYCLOTRIMERIZATION, TRIMETHOPRIM, ATROPISOMERS, DERIVATIVES",

author = "Jonathan Clayden and Moran, {Wesley J.}",

note = "Clayden, Jonathan Moran, Wesley J. 26 ROYAL SOC CHEMISTRY CAMBRIDGE 148TW",

year = "2007",

doi = "10.1039/b700353f",

language = "English",

volume = "5",

pages = "1028--1030",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "7",

}

TY - JOUR

T1 - Synthesis of densely functionalised arenes using [2 + 2 + 2] cycloaddition reactions

AU - Clayden, Jonathan

AU - Moran, Wesley J.

N1 - Clayden, Jonathan Moran, Wesley J. 26 ROYAL SOC CHEMISTRY CAMBRIDGE 148TW

PY - 2007

Y1 - 2007

N2 - Rh(i)-catalysed [2 + 2 + 2] cycloaddition allows the synthesis of aryl ethers and diaryl methanes containing a high degree of steric hindrance from relatively simple diyne and alkyne precursors. The diarylmethanes made in this way show no evidence in their NMR spectra, however, of rotational restriction. This journal is © The Royal Society of Chemistry.

AB - Rh(i)-catalysed [2 + 2 + 2] cycloaddition allows the synthesis of aryl ethers and diaryl methanes containing a high degree of steric hindrance from relatively simple diyne and alkyne precursors. The diarylmethanes made in this way show no evidence in their NMR spectra, however, of rotational restriction. This journal is © The Royal Society of Chemistry.

KW - SUBSTITUTED DIARYL ETHERS

KW - DIHYDROFOLATE-REDUCTASE

KW - ENANTIOSELECTIVE

KW - SYNTHESIS

KW - PNEUMOCYSTIS-CARINII

KW - MYCOBACTERIUM-AVIUM

KW - TOXOPLASMA-GONDII

KW - CYCLOTRIMERIZATION

KW - TRIMETHOPRIM

KW - ATROPISOMERS

KW - DERIVATIVES

U2 - 10.1039/b700353f

DO - 10.1039/b700353f

M3 - Article

SN - 1477-0520

VL - 5

SP - 1028

EP - 1030

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 7

ER -

Synthesis of densely functionalised arenes using [2 + 2 + 2] cycloaddition reactions

Abstract

Keywords

Access to Document

Fingerprint

Cite this