Synthesis of enantiomerically enriched isotopically-labelled anilines by (-)-sparteine directed lithiation

Jonathan Clayden, Loïc Lemiègre, Mark Pickworth

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Anilines bearing benzyl or isopropyl groups isotopically labelled (with 2H or 13C) in one of a pair of enantiotopic protons or methyl groups can be made using (-)-sparteine-directed lithiation with an electrophilic quench, followed by deprotection. © 2008 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)2218-2221
    Number of pages3
    JournalTetrahedron Asymmetry
    Volume19
    Issue number18
    DOIs
    Publication statusPublished - 22 Sept 2008

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