Synthesis of lipidic amino and dipeptide inhibitors of human platelet phospholipase A2

G Kokotos, V Constantinou-Kokotou, C Noula, Anna Nicolaou, WA Gibbons

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Abstract

    Phospholipases A2 (PLA2s) catalyze the hydrolysis of glycerophospholipids at the sn-2 position, and their inhibition is considered a rational approach for the prevention and treatment of inflammation. A number of amides and esters of alpha-amino acids with saturated linear side chains, esters of alpha-amino alcohols and derivatives of lipidic peptides were prepared and tested against secreted humal platelet phospholipase A2. Among the compounds tested the amides of free amino acids with long-chain amines presented the highest in vitro inhibitory activity.
    Original languageEnglish
    Pages (from-to)160-166
    Number of pages7
    JournalInternational Journal of Peptide and Protein Research
    Volume48
    Issue number2
    DOIs
    Publication statusPublished - 1996

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