Synthesis of monolysyl advanced glycation endproducts and their incorporation into collagen model peptides

Tom M. Woods, Meder Kamalov, Paul W R Harris, Garth J S Cooper, Margaret Brimble

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The synthesis of advanced glycation endproducts (AGEs), CML, CEL, and pyrraline and their incorporation into collagen model peptides is reported. AGEs are modified amino acids that form on proteins such as collagen and are thought to play a significant role in the pathogenesis of many diseases, particularly diabetes. The synthesis and incorporation of these compounds into synthetic peptides is a key step in developing model systems with which to investigate AGE-modified proteins. © 2012 American Chemical Society.
    Original languageEnglish
    Pages (from-to)5740-5743
    Number of pages3
    JournalOrganic Letters
    Volume14
    Issue number22
    DOIs
    Publication statusPublished - 16 Nov 2012

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