Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi

R.M. Van Well; B.Y.M. Collet; R.A. Field

doi:10.1055/s-2008-1078249

Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi

R.M. Van Well
, B.Y.M. Collet
, R.A. Field

Manchester Institute of Biotechnology

Research output: Contribution to journal › Letter › peer-review

Abstract

A short, blockwise, 2+2-glycosylation approach to the synthesis of a tetrasaccharide component of Trypanosoma cruzi mucin is reported. Despite the use of a 1,2-linked disaccharide donor, high yield (79%) and good stereocontrol (>10:1, β:α) were achieved in the key glycosylation step. Preliminary studies indicate that this branched tetrasaccharide can serve as a substrate for enzymatic sialylation by the parasite cell surface trans-sialidase.

Original language	Undefined
Pages (from-to)	2175-2177
Number of pages	3
Journal	SYNLETT
Volume	14
DOIs	https://doi.org/10.1055/s-2008-1078249
Publication status	Published - 5 Aug 2008

Keywords

oligosaccharide
synthesis
parasite
mucin
trans-sialidase
drug target

Research Highlights, Institutes and Platforms

Manchester Institute of Biotechnology

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10.1055/s-2008-1078249

Cite this

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title = "Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi",

abstract = "A short, blockwise, 2+2-glycosylation approach to the synthesis of a tetrasaccharide component of Trypanosoma cruzi mucin is reported. Despite the use of a 1,2-linked disaccharide donor, high yield (79\%) and good stereocontrol (>10:1, β:α) were achieved in the key glycosylation step. Preliminary studies indicate that this branched tetrasaccharide can serve as a substrate for enzymatic sialylation by the parasite cell surface trans-sialidase.",

keywords = "oligosaccharide, synthesis, parasite, mucin, trans-sialidase, drug target",

author = "\{Van Well\}, R.M. and B.Y.M. Collet and R.A. Field",

year = "2008",

month = aug,

day = "5",

doi = "10.1055/s-2008-1078249",

language = "Undefined",

volume = "14",

pages = "2175--2177 ",

journal = "SYNLETT",

issn = "0936-5214",

publisher = "Georg Thieme Verlag",

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TY - JOUR

T1 - Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi

AU - Van Well, R.M.

AU - Collet, B.Y.M.

AU - Field, R.A.

PY - 2008/8/5

Y1 - 2008/8/5

N2 - A short, blockwise, 2+2-glycosylation approach to the synthesis of a tetrasaccharide component of Trypanosoma cruzi mucin is reported. Despite the use of a 1,2-linked disaccharide donor, high yield (79%) and good stereocontrol (>10:1, β:α) were achieved in the key glycosylation step. Preliminary studies indicate that this branched tetrasaccharide can serve as a substrate for enzymatic sialylation by the parasite cell surface trans-sialidase.

AB - A short, blockwise, 2+2-glycosylation approach to the synthesis of a tetrasaccharide component of Trypanosoma cruzi mucin is reported. Despite the use of a 1,2-linked disaccharide donor, high yield (79%) and good stereocontrol (>10:1, β:α) were achieved in the key glycosylation step. Preliminary studies indicate that this branched tetrasaccharide can serve as a substrate for enzymatic sialylation by the parasite cell surface trans-sialidase.

KW - oligosaccharide

KW - synthesis

KW - parasite

KW - mucin

KW - trans-sialidase

KW - drug target

UR - https://www.scopus.com/pages/publications/51149108304

U2 - 10.1055/s-2008-1078249

DO - 10.1055/s-2008-1078249

M3 - Letter

SN - 0936-5214

VL - 14

SP - 2175

EP - 2177

JO - SYNLETT

JF - SYNLETT

ER -

Synthesis of mucin glycans from the protozoon parasite Trypanosoma cruzi

Abstract

Keywords

Research Highlights, Institutes and Platforms

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