TY - JOUR
T1 - Synthesis of novel 1-, 1,4- and 1,7-substituted 2-mercapto- and 2-methylmercapto- benzimidazoles: Acyclic analogues of the HIV-1 RT inhibitor, TIBO
AU - M. Gardiner, John
AU - R. Loyns, Colin
PY - 1995/10/16
Y1 - 1995/10/16
N2 - Synthetic approaches towards acyclic analogues of the HIV-1 RT inhibitor TIBO ring system, lacking either the diazepine C7 methylene, C5-N6 bond or the N1-N6 two-carbon bridge, are reported, utilizing ring opening reactions of 2-methylaziridines. A number of isomeric 2-methylmercaptobenzimidazole analogues have also been prepared, and the regiochemistry of 2-methylmercaptobenzimidazole alkylations is discussed, as a convenient route to 1,2,7-trifunctionalized benzimidazoles. © 1995 Elsevier Science Ltd, Printed in Great Britain. All rights reserved.
AB - Synthetic approaches towards acyclic analogues of the HIV-1 RT inhibitor TIBO ring system, lacking either the diazepine C7 methylene, C5-N6 bond or the N1-N6 two-carbon bridge, are reported, utilizing ring opening reactions of 2-methylaziridines. A number of isomeric 2-methylmercaptobenzimidazole analogues have also been prepared, and the regiochemistry of 2-methylmercaptobenzimidazole alkylations is discussed, as a convenient route to 1,2,7-trifunctionalized benzimidazoles. © 1995 Elsevier Science Ltd, Printed in Great Britain. All rights reserved.
U2 - 10.1016/0040-4020(95)00751-S
DO - 10.1016/0040-4020(95)00751-S
M3 - Article
SN - 0040-4020
VL - 51
SP - 11515
EP - 11530
JO - Tetrahedron
JF - Tetrahedron
IS - 42
ER -
