Synthesis of novel 5-amino-6-ethoxy-2-alkyl-4-pyrimidinecarbonitriles.

Amal Al-Azmi, Brian L. Booth, Robin G. Pritchard, Fernanda J. R. P. Proenca

    Research output: Contribution to journalArticlepeer-review


    Formation of highly functionalized 5-amino-6-ethoxy-2-alkylpyrimidine-4-carbonitriles was shown to occur by simply refluxing (Z)-N-(2-amino-1,2-dicyanoethenyl)acetamide hydrochloride or (Z)-N-(2-amino-1,2-dicyanoethenyl)pentanamide hydrochloride in ethanol under acid catalysis conditions. In the absence of acidic catalysis the reaction of 2,3-diaminomaleonitrile with acetic anhydride in ethanol gave (Z)-N-(2-amino-1,2-dicyanoethenyl)acetamide.
    Original languageEnglish
    JournalJournal of the Chemical Society, Perkin Transactions 1
    Publication statusPublished - 2001


    • Crystal structure; Molecular structure (of aminoethoxymethylpyrimidinecarbonitrile); Cyclization (prepn. of amino(alkoxy)(alkyl)pyrimidinecarbonitriles by cyclization of N-(aminodicyanoethenyl)carboxamide hydrochlorides)


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