Synthesis of polyacid nanogels: pH-responsive sub-100 nm particles for functionalisation and fluorescent hydrogel assembly

Amir H. Milani, Jennifer Saunders, Nam Nguyen, Liam P D Ratcliffe, Daman Adlam, Anthony Freemont, Judith Hoyland, Steven P Armes, Brian Saunders

Research output: Contribution to journalArticlepeer-review

55 Downloads (Pure)

Abstract

Nanogels are crosslinked polymer particles with a swollen size between 1 and 100 nm. They are of major interest for advanced surface coatings, drug delivery, diagnostics and biomaterials. Synthesising polyacid nanogels that show triggered swelling using a scalable approach is a key objective of polymer colloid chemistry. Inspired by the ability of polar surfaces to enhance nanoparticle stabilisation, we report the first examples of pH-responsive polyacid nanogels containing high –COOH contents prepared by a simple, scalable, aqueous method. To demonstrate their functionalisation potential, glycidyl methacrylate was reacted with the –COOH chemical handles and the nanogels were converted to macro-crosslinkers. The concentrated (functionalised) nanogel dispersions retained their pH-responsiveness, were shear-thinning and formed physical gels at pH 7.4. The nanogels were covalently interlinked via free-radical coupling at 37 °C to form transparent, ductile, hydrogels. Mixing of the functionalised nanogels with polymer dots enabled covalent assembly of fluorescent hydrogels.
Original languageEnglish
Pages (from-to)1554-1560
JournalSoft Matter
Volume13
DOIs
Publication statusPublished - 25 Jan 2017

Fingerprint

Dive into the research topics of 'Synthesis of polyacid nanogels: pH-responsive sub-100 nm particles for functionalisation and fluorescent hydrogel assembly'. Together they form a unique fingerprint.

Cite this