Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin

C. Bernlind; S.W. Homans; R.A. Field

doi:10.1016/j.tetlet.2009.02.131

Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin

C. Bernlind, S.W. Homans, R.A. Field

Manchester Institute of Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of new potential ligands for Escherichia coli 0157 verotoxin is reported, based on disaccharide fragments of the tetrasaccharide glycan portion of Gb4 glycolipid. Intramolecular aglycone delivery was employed for the high-yielding and stereoselective production of the azidopropyl-tethered α-galactoside building block.

Original language	Undefined
Pages (from-to)	3397-3399
Number of pages	3
Journal	Tetrahedron Letters
Volume	50
Issue number	26
DOIs	https://doi.org/10.1016/j.tetlet.2009.02.131
Publication status	Published - 21 Feb 2009

Keywords

Gb3
Gb4
Glycosylation
Disaccharide
Intramolecular aglycone delivery (IAD)

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

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10.1016/j.tetlet.2009.02.131

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abstract = "The synthesis of new potential ligands for Escherichia coli 0157 verotoxin is reported, based on disaccharide fragments of the tetrasaccharide glycan portion of Gb4 glycolipid. Intramolecular aglycone delivery was employed for the high-yielding and stereoselective production of the azidopropyl-tethered α-galactoside building block.",

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AU - Bernlind, C.

AU - Homans, S.W.

AU - Field, R.A.

PY - 2009/2/21

Y1 - 2009/2/21

N2 - The synthesis of new potential ligands for Escherichia coli 0157 verotoxin is reported, based on disaccharide fragments of the tetrasaccharide glycan portion of Gb4 glycolipid. Intramolecular aglycone delivery was employed for the high-yielding and stereoselective production of the azidopropyl-tethered α-galactoside building block.

AB - The synthesis of new potential ligands for Escherichia coli 0157 verotoxin is reported, based on disaccharide fragments of the tetrasaccharide glycan portion of Gb4 glycolipid. Intramolecular aglycone delivery was employed for the high-yielding and stereoselective production of the azidopropyl-tethered α-galactoside building block.

KW - Gb3

KW - Gb4

KW - Glycosylation

KW - Disaccharide

KW - Intramolecular aglycone delivery (IAD)

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-65549125049&partnerID=MN8TOARS

U2 - 10.1016/j.tetlet.2009.02.131

DO - 10.1016/j.tetlet.2009.02.131

M3 - Article

SN - 0040-4039

VL - 50

SP - 3397

EP - 3399

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 26

ER -

Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin

Abstract

Keywords

Research Beacons, Institutes and Platforms

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