Abstract
Multi-enzyme cascades utilising variants of galactose oxidase and imine reductase led to the successful conversion of N-Cbz-protected l-ornithinol and l-lysinol to l-3-N-Cbz-aminopiperidine and l-3-N-Cbz-aminoazepane respectively, in up to 54% isolated yield. Streamlining the reactions into one-pot prevented potential racemisation of key labile intermediates and led to products with high enantiopurity.
Original language | English |
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Pages (from-to) | 7949-7952 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 56 |
Issue number | 57 |
DOIs | |
Publication status | Published - 21 Jul 2020 |