Synthetic biology approaches to actinomycete strain improvement

Rainer Breitling, Martina Avbelj, Oksana Bilyk, Francesco Del Carratore, Alessandro Filisetti, Erik K R Hanko, Marianna Iorio, Rosario Pérez Redondo, Fernando Reyes, Michelle Rudden, Emmanuele Severi, Lucija Slemc, Kamila Schmidt, Dominic R Whittall, Stefano Donadio, Antonio Rodríguez García, Olga Genilloud, Gregor Kosec, Davide De Lucrezia, Hrvoje PetkovićGavin Thomas, Eriko Takano

Research output: Contribution to journalArticlepeer-review


Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.
Original languageEnglish
JournalFEMS microbiology letters
Early online date31 May 2021
Publication statusPublished - 31 May 2021

Research Beacons, Institutes and Platforms

  • Manchester Institute of Biotechnology


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