Synthetic biology approaches to actinomycete strain improvement

Rainer Breitling; Martina Avbelj; Oksana Bilyk; Francesco Del Carratore; Alessandro Filisetti; Erik K R Hanko; Marianna Iorio; Rosario Pérez Redondo; Fernando Reyes; Michelle Rudden; Emmanuele Severi; Lucija Slemc; Kamila Schmidt; Dominic R Whittall; Stefano Donadio; Antonio Rodríguez García; Olga Genilloud; Gregor Kosec; Davide De Lucrezia; Hrvoje Petković; Gavin Thomas; Eriko Takano

doi:10.1093/femsle/fnab060

Synthetic biology approaches to actinomycete strain improvement

Rainer Breitling, Martina Avbelj, Oksana Bilyk, Francesco Del Carratore, Alessandro Filisetti, Erik K R Hanko, Marianna Iorio, Rosario Pérez Redondo, Fernando Reyes, Michelle Rudden, Emmanuele Severi, Lucija Slemc, Kamila Schmidt, Dominic R Whittall, Stefano Donadio, Antonio Rodríguez García, Olga Genilloud, Gregor Kosec, Davide De Lucrezia, Hrvoje PetkovićGavin Thomas, Eriko Takano

Research output: Contribution to journal › Article › peer-review

Abstract

Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.

Original language	English
Journal	FEMS microbiology letters
Early online date	31 May 2021
DOIs	https://doi.org/10.1093/femsle/fnab060
Publication status	Published - 31 May 2021

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Manchester Institute of Biotechnology

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10.1093/femsle/fnab060

https://academic.oup.com/femsle/advance-article/doi/10.1093/femsle/fnab060/6289918

Manchester Synthetic Biology Research Centre for Fine and Speciality Chemicals
Scrutton, N. (PI), Azapagic, A. (CoI), Balmer, A. (CoI), Barran, P. (CoI), Breitling, R. (CoI), Delneri, D. (CoI), Dixon, N. (CoI), Faulon, J.-L. (CoI), Flitsch, S. (CoI), Goble, C. (CoI), Goodacre, R. (CoI), Hay, S. (CoI), Kell, D. (CoI), Leys, D. (CoI), Lloyd, J. (CoI), Lockyer, N. (CoI), Martin, P. (CoI), Micklefield, J. (CoI), Munro, A. (CoI), Pedrosa Mendes, P. (CoI), Randles, S. (CoI), Salehi Yazdi, F. (CoI), Shapira, P. (CoI), Takano, E. (CoI), Turner, N. (CoI) & Winterburn, J. (CoI)
14/11/14 → 13/05/20
Project: Research

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Breitling, R., Avbelj, M., Bilyk, O., Del Carratore, F., Filisetti, A., Hanko, E. K. R., Iorio, M., Redondo, R. P., Reyes, F., Rudden, M., Severi, E., Slemc, L., Schmidt, K., Whittall, D. R., Donadio, S., García, A. R., Genilloud, O., Kosec, G., De Lucrezia, D., ... Takano, E. (2021). Synthetic biology approaches to actinomycete strain improvement. FEMS microbiology letters. https://doi.org/10.1093/femsle/fnab060

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title = "Synthetic biology approaches to actinomycete strain improvement",

abstract = "Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.",

author = "Rainer Breitling and Martina Avbelj and Oksana Bilyk and {Del Carratore}, Francesco and Alessandro Filisetti and Hanko, {Erik K R} and Marianna Iorio and Redondo, {Rosario P{\'e}rez} and Fernando Reyes and Michelle Rudden and Emmanuele Severi and Lucija Slemc and Kamila Schmidt and Whittall, {Dominic R} and Stefano Donadio and Garc{\'i}a, {Antonio Rodr{\'i}guez} and Olga Genilloud and Gregor Kosec and {De Lucrezia}, Davide and Hrvoje Petkovi{\'c} and Gavin Thomas and Eriko Takano",

year = "2021",

month = may,

day = "31",

doi = "10.1093/femsle/fnab060",

language = "English",

journal = "FEMS microbiology letters",

issn = "0378-1097",

publisher = "John Wiley & Sons Ltd",

}

Breitling, R, Avbelj, M, Bilyk, O, Del Carratore, F, Filisetti, A, Hanko, EKR, Iorio, M, Redondo, RP, Reyes, F, Rudden, M, Severi, E, Slemc, L, Schmidt, K, Whittall, DR, Donadio, S, García, AR, Genilloud, O, Kosec, G, De Lucrezia, D, Petković, H, Thomas, G & Takano, E 2021, 'Synthetic biology approaches to actinomycete strain improvement', FEMS microbiology letters. https://doi.org/10.1093/femsle/fnab060

TY - JOUR

T1 - Synthetic biology approaches to actinomycete strain improvement

AU - Breitling, Rainer

AU - Avbelj, Martina

AU - Bilyk, Oksana

AU - Del Carratore, Francesco

AU - Filisetti, Alessandro

AU - Hanko, Erik K R

AU - Iorio, Marianna

AU - Redondo, Rosario Pérez

AU - Reyes, Fernando

AU - Rudden, Michelle

AU - Severi, Emmanuele

AU - Slemc, Lucija

AU - Schmidt, Kamila

AU - Whittall, Dominic R

AU - Donadio, Stefano

AU - García, Antonio Rodríguez

AU - Genilloud, Olga

AU - Kosec, Gregor

AU - De Lucrezia, Davide

AU - Petković, Hrvoje

AU - Thomas, Gavin

AU - Takano, Eriko

PY - 2021/5/31

Y1 - 2021/5/31

N2 - Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.

AB - Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.

U2 - 10.1093/femsle/fnab060

DO - 10.1093/femsle/fnab060

M3 - Article

SN - 0378-1097

JO - FEMS microbiology letters

JF - FEMS microbiology letters

ER -

Synthetic biology approaches to actinomycete strain improvement

Abstract

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Manchester Synthetic Biology Research Centre for Fine and Speciality Chemicals

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