Synthetic enzyme‐catalysed CO2 fixation reactions

Godwin A Aleku, George W. Roberts, Gabriel R. Titchiner, David Leys

Research output: Contribution to journalArticlepeer-review

31 Downloads (Pure)


In recent years, (de)carboxylases catalysing reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof of concept (bio)synthetic CO 2 ‐fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO 2 to organic molecules. Herein, we review biocatalytic carboxylation methods, with emphasis on the diverse strategies devised to alleviate the inherent thermodynamic constraints, and their application in synthetic CO 2 ‐fixation cascades.
Original languageEnglish
Publication statusPublished - 25 Feb 2021


Dive into the research topics of 'Synthetic enzyme‐catalysed CO2 fixation reactions'. Together they form a unique fingerprint.

Cite this