Synthetic enzyme‐catalysed CO2 fixation reactions

Godwin A Aleku; George W. Roberts; Gabriel R. Titchiner; David Leys

doi:10.1002/cssc.202100159

Synthetic enzyme‐catalysed CO2 fixation reactions

Godwin A Aleku, George W. Roberts, Gabriel R. Titchiner, David Leys

Research output: Contribution to journal › Article › peer-review

40 Downloads (Pure)

Abstract

In recent years, (de)carboxylases catalysing reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof of concept (bio)synthetic CO 2 ‐fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO 2 to organic molecules. Herein, we review biocatalytic carboxylation methods, with emphasis on the diverse strategies devised to alleviate the inherent thermodynamic constraints, and their application in synthetic CO 2 ‐fixation cascades.

Original language	English
Journal	Chemsuschem
DOIs	https://doi.org/10.1002/cssc.202100159
Publication status	Published - 25 Feb 2021

Access to Document

10.1002/cssc.202100159Licence: Other

Carboxylation review_revision_Final1_non-highlightedAccepted author manuscript, 3.55 MB

https://onlinelibrary.wiley.com/doi/10.1002/cssc.202100159

Cite this

@article{b44d9ee9e5d44ef292052085f56d13b3,

title = "Synthetic enzyme‐catalysed CO2 fixation reactions",

abstract = "In recent years, (de)carboxylases catalysing reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof of concept (bio)synthetic CO 2 ‐fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO 2 to organic molecules. Herein, we review biocatalytic carboxylation methods, with emphasis on the diverse strategies devised to alleviate the inherent thermodynamic constraints, and their application in synthetic CO 2 ‐fixation cascades.",

author = "Aleku, {Godwin A} and Roberts, {George W.} and Titchiner, {Gabriel R.} and David Leys",

year = "2021",

month = feb,

day = "25",

doi = "10.1002/cssc.202100159",

language = "English",

journal = "Chemsuschem",

issn = "1864-5631",

publisher = "John Wiley & Sons Ltd",

}

TY - JOUR

T1 - Synthetic enzyme‐catalysed CO2 fixation reactions

AU - Aleku, Godwin A

AU - Roberts, George W.

AU - Titchiner, Gabriel R.

AU - Leys, David

PY - 2021/2/25

Y1 - 2021/2/25

N2 - In recent years, (de)carboxylases catalysing reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof of concept (bio)synthetic CO 2 ‐fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO 2 to organic molecules. Herein, we review biocatalytic carboxylation methods, with emphasis on the diverse strategies devised to alleviate the inherent thermodynamic constraints, and their application in synthetic CO 2 ‐fixation cascades.

AB - In recent years, (de)carboxylases catalysing reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof of concept (bio)synthetic CO 2 ‐fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO 2 to organic molecules. Herein, we review biocatalytic carboxylation methods, with emphasis on the diverse strategies devised to alleviate the inherent thermodynamic constraints, and their application in synthetic CO 2 ‐fixation cascades.

U2 - 10.1002/cssc.202100159

DO - 10.1002/cssc.202100159

M3 - Article

SN - 1864-5631

JO - Chemsuschem

JF - Chemsuschem

ER -

Synthetic enzyme‐catalysed CO2 fixation reactions

Abstract

Access to Document

Fingerprint

Cite this