TY - JOUR
T1 - Synthetic enzyme‐catalysed CO2 fixation reactions
AU - Aleku, Godwin A
AU - Roberts, George W.
AU - Titchiner, Gabriel R.
AU - Leys, David
PY - 2021/2/25
Y1 - 2021/2/25
N2 - In recent years, (de)carboxylases catalysing reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof of concept (bio)synthetic CO 2 ‐fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO 2 to organic molecules. Herein, we review biocatalytic carboxylation methods, with emphasis on the diverse strategies devised to alleviate the inherent thermodynamic constraints, and their application in synthetic CO 2 ‐fixation cascades.
AB - In recent years, (de)carboxylases catalysing reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof of concept (bio)synthetic CO 2 ‐fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO 2 to organic molecules. Herein, we review biocatalytic carboxylation methods, with emphasis on the diverse strategies devised to alleviate the inherent thermodynamic constraints, and their application in synthetic CO 2 ‐fixation cascades.
UR - https://www.scopus.com/pages/publications/85102347508
U2 - 10.1002/cssc.202100159
DO - 10.1002/cssc.202100159
M3 - Article
SN - 1864-5631
JO - Chemsuschem
JF - Chemsuschem
ER -