Systematic review and meta-analysis of the efficacy of statins in experimental stroke

Hardaman K. Baryan; Stuart M. Allan; Andy Vail; Craig J. Smith

doi:10.1111/j.1747-4949.2011.00740.x

Systematic review and meta-analysis of the efficacy of statins in experimental stroke

Hardaman K. Baryan, Stuart M. Allan, Andy Vail, Craig J. Smith

Research output: Contribution to journal › Article › peer-review

Abstract

Background and purpose: Statins are postulated as candidate drugs for the treatment of acute stroke. The aim of this study was to critically appraise the evidence for the efficacy of statins administered after the onset of experimental focal cerebral ischemia. Methods: We undertook a systematic review and meta-analysis of animal studies reporting the efficacy of any statin administered following middle cerebral artery occlusion. The primary outcome measure was infarct volume. Assessment of study quality and range of evidence were undertaken, and prespecified sub-group analyses were performed. Results: Eighteen published studies describing outcome in 472 animals were identified. Statins reduced infarct volume by 11·2% (95% confidence interval 8·1% to 14·3%, P

Original language	English
Pages (from-to)	150-156
Number of pages	6
Journal	International Journal of Stroke
Volume	7
Issue number	2
DOIs	https://doi.org/10.1111/j.1747-4949.2011.00740.x
Publication status	Published - Feb 2012

Keywords

Meta-analysis
Neuroprotection
Preclinical
Statins
Stroke
Systematic review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1747-4949.2011.00740.x

Cite this

@article{e4bcd61119464fdd9c9542f0ef05cf03,

title = "Systematic review and meta-analysis of the efficacy of statins in experimental stroke",

abstract = "Background and purpose: Statins are postulated as candidate drugs for the treatment of acute stroke. The aim of this study was to critically appraise the evidence for the efficacy of statins administered after the onset of experimental focal cerebral ischemia. Methods: We undertook a systematic review and meta-analysis of animal studies reporting the efficacy of any statin administered following middle cerebral artery occlusion. The primary outcome measure was infarct volume. Assessment of study quality and range of evidence were undertaken, and prespecified sub-group analyses were performed. Results: Eighteen published studies describing outcome in 472 animals were identified. Statins reduced infarct volume by 11·2% (95% confidence interval 8·1% to 14·3%, P",

keywords = "Meta-analysis, Neuroprotection, Preclinical, Statins, Stroke, Systematic review",

author = "Baryan, {Hardaman K.} and Allan, {Stuart M.} and Andy Vail and Smith, {Craig J.}",

year = "2012",

month = feb,

doi = "10.1111/j.1747-4949.2011.00740.x",

language = "English",

volume = "7",

pages = "150--156",

journal = "International Journal of Stroke",

issn = "1747-4930",

publisher = "Sage Publications Ltd",

number = "2",

}

TY - JOUR

T1 - Systematic review and meta-analysis of the efficacy of statins in experimental stroke

AU - Baryan, Hardaman K.

AU - Allan, Stuart M.

AU - Vail, Andy

AU - Smith, Craig J.

PY - 2012/2

Y1 - 2012/2

N2 - Background and purpose: Statins are postulated as candidate drugs for the treatment of acute stroke. The aim of this study was to critically appraise the evidence for the efficacy of statins administered after the onset of experimental focal cerebral ischemia. Methods: We undertook a systematic review and meta-analysis of animal studies reporting the efficacy of any statin administered following middle cerebral artery occlusion. The primary outcome measure was infarct volume. Assessment of study quality and range of evidence were undertaken, and prespecified sub-group analyses were performed. Results: Eighteen published studies describing outcome in 472 animals were identified. Statins reduced infarct volume by 11·2% (95% confidence interval 8·1% to 14·3%, P

AB - Background and purpose: Statins are postulated as candidate drugs for the treatment of acute stroke. The aim of this study was to critically appraise the evidence for the efficacy of statins administered after the onset of experimental focal cerebral ischemia. Methods: We undertook a systematic review and meta-analysis of animal studies reporting the efficacy of any statin administered following middle cerebral artery occlusion. The primary outcome measure was infarct volume. Assessment of study quality and range of evidence were undertaken, and prespecified sub-group analyses were performed. Results: Eighteen published studies describing outcome in 472 animals were identified. Statins reduced infarct volume by 11·2% (95% confidence interval 8·1% to 14·3%, P

KW - Meta-analysis

KW - Neuroprotection

KW - Preclinical

KW - Statins

KW - Stroke

KW - Systematic review

U2 - 10.1111/j.1747-4949.2011.00740.x

DO - 10.1111/j.1747-4949.2011.00740.x

M3 - Article

C2 - 22264368

SN - 1747-4930

VL - 7

SP - 150

EP - 156

JO - International Journal of Stroke

JF - International Journal of Stroke

IS - 2

ER -

Systematic review and meta-analysis of the efficacy of statins in experimental stroke

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this