Systematic review of the safety and efficacy of antazoline in the treatment of atrial fibrillation

Raghad Falah Dawood Aldulaymi, Ahmad Al Meslamani

Research output: Contribution to journalArticlepeer-review


Context: In the emergency department, patients with recent-onset atrial fibrillation are typically managed with intravenous antiarrhythmic agents.
However, the currently used agents have a low efficacy and safety profile. Antazoline is an antihistaminic agent that has been shown to have a
strong antiarrhythmic effect when administered intravenously, facilitating rapid conversion to normal sinus rhythm.
Aims: To systematically review the literature on the safety and efficacy of antazoline in the treatment of recent-onset short-duration atrial fibrillation
and to compare the clinical efficacy of antazoline to that of other antiarrhythmic agents listed in clinical guidelines.
Methods: The study was written in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. A
comprehensive search of databases (PubMed, Scopus, ScienceDirect, Web of Sciences, Google Scholar, Clinical for relevant studies in
English from inception to 2021 using keywords involving "antazoline" AND other terms such as "antiarrhythmic", "atrial fibrillation", and
Results: Of the 478 studies identified, 446 were screened, and 7 were included, one of which was a randomized control trial, and the others were
observational studies. The majority of studies indicated that antazoline resulted in rapid cardioversion to sinus rhythm. When compared to other
pharmacological cardioversion options, antazoline achieved higher cardioversion rates than amiodarone or propafenone and was generally a safer option.
Conclusions: Antazoline appears to be an effective pharmacological agent for the rapid cardioversion of short-term atrial fibrillation. More
randomized clinical trials, however, should be conducted to strengthen the evidence.
Original languageEnglish
Pages (from-to) 147-157
JournalJournal of Pharmacy & Pharmacognosy Research
Issue number1
Publication statusPublished - 4 Oct 2021
Externally publishedYes


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