Systems Biology Guided by XCMS Online Metabolomics

Tao Huan; Erica M. Forsberg; Duane Rinehart; Caroline H. Johnson; Julijana Ivanisevic; H. Paul Benton; Mingliang Fang; Aries Aisporna; Brian Hilmers; Farris L. Poole; Michael P. Thorgersen; Michael W. W. Adams; Gregory Krantz; Matthew W. Fields; Paul Robbins; Laura J. Niedernhofer; Trey Ideker; Erica L. Majumder; Judy D. Wall; Nicholas Rattray; Royston Goodacre; Luke Lairson; Gary Siuzdak

doi:10.1038/nmeth.4260

Systems Biology Guided by XCMS Online Metabolomics

Tao Huan, Erica M. Forsberg, Duane Rinehart, Caroline H. Johnson, Julijana Ivanisevic, H. Paul Benton, Mingliang Fang, Aries Aisporna, Brian Hilmers, Farris L. Poole, Michael P. Thorgersen, Michael W. W. Adams, Gregory Krantz, Matthew W. Fields, Paul Robbins, Laura J. Niedernhofer, Trey Ideker, Erica L. Majumder, Judy D. Wall, Nicholas RattrayRoyston Goodacre, Luke Lairson, Gary Siuzdak

Research output: Contribution to journal › Article › peer-review

79 Downloads (Pure)

Abstract

An aim of systems biology is to understand complex interactions between genes, proteins and metabolites by integrating and modeling multiple data sources. We report an 'integrated-omics' approach within XCMS Online1 that automatically superimposes raw metabolomic data onto metabolic pathways and integrates it with transcriptomic and proteomic data.

Original language	English
Pages (from-to)	461-462
Number of pages	2
Journal	Nature Methods
Volume	14
Early online date	27 Apr 2017
DOIs	https://doi.org/10.1038/nmeth.4260
Publication status	Published - 27 Apr 2017

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

Access to Document

10.1038/nmeth.4260

2017-03-20 NMeth XCMS SystemsAccepted author manuscript, 7.27 MB

Manchester Synthetic Biology Research Centre for Fine and Speciality Chemicals
Scrutton, N. (PI), Azapagic, A. (CoI), Balmer, A. (CoI), Barran, P. (CoI), Breitling, R. (CoI), Delneri, D. (CoI), Dixon, N. (CoI), Faulon, J.-L. (CoI), Flitsch, S. (CoI), Goble, C. (CoI), Goodacre, R. (CoI), Hay, S. (CoI), Kell, D. (CoI), Leys, D. (CoI), Lloyd, J. (CoI), Lockyer, N. (CoI), Martin, P. (CoI), Micklefield, J. (CoI), Munro, A. (CoI), Pedrosa Mendes, P. (CoI), Randles, S. (CoI), Salehi Yazdi, F. (CoI), Shapira, P. (CoI), Takano, E. (CoI), Turner, N. (CoI) & Winterburn, J. (CoI)
14/11/14 → 13/05/20
Project: Research
Inequalities in later life frailty and wellbeing: an interdisciplinary approach to causality: Full bid
Nazroo, J. (PI), Burns, A. (CoI), Chandola, T. (CoI), Goodacre, R. (CoI), Horan, M. (CoI), Pendleton, N. (CoI), Tampubolon, G. (CoI) & Wu, F. (CoI)
1/11/11 → 31/12/16
Project: Research

Cite this

Huan, T., Forsberg, E. M., Rinehart, D., Johnson, C. H., Ivanisevic, J., Benton, H. P., Fang, M., Aisporna, A., Hilmers, B., Poole, F. L., Thorgersen, M. P., Adams, M. W. W., Krantz, G., Fields, M. W., Robbins, P., Niedernhofer, L. J., Ideker, T., Majumder, E. L., Wall, J. D., ... Siuzdak, G. (2017). Systems Biology Guided by XCMS Online Metabolomics. Nature Methods, 14, 461-462. https://doi.org/10.1038/nmeth.4260

@article{cdc28e24ece14bf08f8843cd081fe3cf,

title = "Systems Biology Guided by XCMS Online Metabolomics",

abstract = "An aim of systems biology is to understand complex interactions between genes, proteins and metabolites by integrating and modeling multiple data sources. We report an 'integrated-omics' approach within XCMS Online1 that automatically superimposes raw metabolomic data onto metabolic pathways and integrates it with transcriptomic and proteomic data.",

author = "Tao Huan and Forsberg, {Erica M.} and Duane Rinehart and Johnson, {Caroline H.} and Julijana Ivanisevic and Benton, {H. Paul} and Mingliang Fang and Aries Aisporna and Brian Hilmers and Poole, {Farris L.} and Thorgersen, {Michael P.} and Adams, {Michael W. W.} and Gregory Krantz and Fields, {Matthew W.} and Paul Robbins and Niedernhofer, {Laura J.} and Trey Ideker and Majumder, {Erica L.} and Wall, {Judy D.} and Nicholas Rattray and Royston Goodacre and Luke Lairson and Gary Siuzdak",

year = "2017",

month = apr,

day = "27",

doi = "10.1038/nmeth.4260",

language = "English",

volume = "14",

pages = "461--462",

journal = "Nature Methods",

issn = "1548-7105",

publisher = "Nature Research",

}

Huan, T, Forsberg, EM, Rinehart, D, Johnson, CH, Ivanisevic, J, Benton, HP, Fang, M, Aisporna, A, Hilmers, B, Poole, FL, Thorgersen, MP, Adams, MWW, Krantz, G, Fields, MW, Robbins, P, Niedernhofer, LJ, Ideker, T, Majumder, EL, Wall, JD, Rattray, N, Goodacre, R, Lairson, L & Siuzdak, G 2017, 'Systems Biology Guided by XCMS Online Metabolomics', Nature Methods, vol. 14, pp. 461-462. https://doi.org/10.1038/nmeth.4260

TY - JOUR

T1 - Systems Biology Guided by XCMS Online Metabolomics

AU - Huan, Tao

AU - Forsberg, Erica M.

AU - Rinehart, Duane

AU - Johnson, Caroline H.

AU - Ivanisevic, Julijana

AU - Benton, H. Paul

AU - Fang, Mingliang

AU - Aisporna, Aries

AU - Hilmers, Brian

AU - Poole, Farris L.

AU - Thorgersen, Michael P.

AU - Adams, Michael W. W.

AU - Krantz, Gregory

AU - Fields, Matthew W.

AU - Robbins, Paul

AU - Niedernhofer, Laura J.

AU - Ideker, Trey

AU - Majumder, Erica L.

AU - Wall, Judy D.

AU - Rattray, Nicholas

AU - Goodacre, Royston

AU - Lairson, Luke

AU - Siuzdak, Gary

PY - 2017/4/27

Y1 - 2017/4/27

N2 - An aim of systems biology is to understand complex interactions between genes, proteins and metabolites by integrating and modeling multiple data sources. We report an 'integrated-omics' approach within XCMS Online1 that automatically superimposes raw metabolomic data onto metabolic pathways and integrates it with transcriptomic and proteomic data.

AB - An aim of systems biology is to understand complex interactions between genes, proteins and metabolites by integrating and modeling multiple data sources. We report an 'integrated-omics' approach within XCMS Online1 that automatically superimposes raw metabolomic data onto metabolic pathways and integrates it with transcriptomic and proteomic data.

U2 - 10.1038/nmeth.4260

DO - 10.1038/nmeth.4260

M3 - Article

SN - 1548-7105

VL - 14

SP - 461

EP - 462

JO - Nature Methods

JF - Nature Methods

ER -

Systems Biology Guided by XCMS Online Metabolomics

Abstract

Research Beacons, Institutes and Platforms

Access to Document

Fingerprint

Projects

Manchester Synthetic Biology Research Centre for Fine and Speciality Chemicals

Inequalities in later life frailty and wellbeing: an interdisciplinary approach to causality: Full bid

Cite this