Systems biology of infectious diseases: A focus on fungal infections

Rodrigo Santamaría, Lisa Rizzetto, Michael Bromley, Teresa Zelante, Wanseon Lee, Duccio Cavalieri, Luigina Romani, Brian Miller, Ivo Gut, Manuel Santos, Philippe Pierre, Paul Bowyer, Misha Kapushesky

    Research output: Contribution to journalArticlepeer-review


    The study of infectious disease concerns the interaction between the host species and a pathogen organism. The analysis of such complex systems is improving with the evolution of high-throughput technologies and advanced computational resources. This article reviews integrative, systems-oriented approaches to understanding mechanisms underlying infection, immune response and inflammation to find biomarkers of disease and design new drugs. We focus on the systems biology process, especially the data gathering and analysis techniques rather than the experimental technologies or latest computational resources. © 2011 Elsevier GmbH.
    Original languageEnglish
    Pages (from-to)1212-1227
    Number of pages15
    Issue number11
    Publication statusPublished - Nov 2011


    • Drug development
    • Fungal diseases
    • Host-pathogen interaction
    • Infectious diseases
    • Systems biology


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