Systems biology of infectious diseases: A focus on fungal infections

Rodrigo Santamaría; Lisa Rizzetto; Michael Bromley; Teresa Zelante; Wanseon Lee; Duccio Cavalieri; Luigina Romani; Brian Miller; Ivo Gut; Manuel Santos; Philippe Pierre; Paul Bowyer; Misha Kapushesky

doi:10.1016/j.imbio.2011.08.004

Systems biology of infectious diseases: A focus on fungal infections

Rodrigo Santamaría, Lisa Rizzetto, Michael Bromley, Teresa Zelante, Wanseon Lee, Duccio Cavalieri, Luigina Romani, Brian Miller, Ivo Gut, Manuel Santos, Philippe Pierre, Paul Bowyer, Misha Kapushesky

Research output: Contribution to journal › Article › peer-review

Abstract

The study of infectious disease concerns the interaction between the host species and a pathogen organism. The analysis of such complex systems is improving with the evolution of high-throughput technologies and advanced computational resources. This article reviews integrative, systems-oriented approaches to understanding mechanisms underlying infection, immune response and inflammation to find biomarkers of disease and design new drugs. We focus on the systems biology process, especially the data gathering and analysis techniques rather than the experimental technologies or latest computational resources. © 2011 Elsevier GmbH.

Original language	English
Pages (from-to)	1212-1227
Number of pages	15
Journal	Immunobiology
Volume	216
Issue number	11
DOIs	https://doi.org/10.1016/j.imbio.2011.08.004
Publication status	Published - Nov 2011

Keywords

Drug development
Fungal diseases
Host-pathogen interaction
Infectious diseases
Systems biology

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10.1016/j.imbio.2011.08.004

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title = "Systems biology of infectious diseases: A focus on fungal infections",

abstract = "The study of infectious disease concerns the interaction between the host species and a pathogen organism. The analysis of such complex systems is improving with the evolution of high-throughput technologies and advanced computational resources. This article reviews integrative, systems-oriented approaches to understanding mechanisms underlying infection, immune response and inflammation to find biomarkers of disease and design new drugs. We focus on the systems biology process, especially the data gathering and analysis techniques rather than the experimental technologies or latest computational resources. {\textcopyright} 2011 Elsevier GmbH.",

keywords = "Drug development, Fungal diseases, Host-pathogen interaction, Infectious diseases, Systems biology",

author = "Rodrigo Santamar{\'i}a and Lisa Rizzetto and Michael Bromley and Teresa Zelante and Wanseon Lee and Duccio Cavalieri and Luigina Romani and Brian Miller and Ivo Gut and Manuel Santos and Philippe Pierre and Paul Bowyer and Misha Kapushesky",

year = "2011",

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doi = "10.1016/j.imbio.2011.08.004",

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volume = "216",

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TY - JOUR

T1 - Systems biology of infectious diseases: A focus on fungal infections

AU - Santamaría, Rodrigo

AU - Rizzetto, Lisa

AU - Bromley, Michael

AU - Zelante, Teresa

AU - Lee, Wanseon

AU - Cavalieri, Duccio

AU - Romani, Luigina

AU - Miller, Brian

AU - Gut, Ivo

AU - Santos, Manuel

AU - Pierre, Philippe

AU - Bowyer, Paul

AU - Kapushesky, Misha

PY - 2011/11

Y1 - 2011/11

N2 - The study of infectious disease concerns the interaction between the host species and a pathogen organism. The analysis of such complex systems is improving with the evolution of high-throughput technologies and advanced computational resources. This article reviews integrative, systems-oriented approaches to understanding mechanisms underlying infection, immune response and inflammation to find biomarkers of disease and design new drugs. We focus on the systems biology process, especially the data gathering and analysis techniques rather than the experimental technologies or latest computational resources. © 2011 Elsevier GmbH.

AB - The study of infectious disease concerns the interaction between the host species and a pathogen organism. The analysis of such complex systems is improving with the evolution of high-throughput technologies and advanced computational resources. This article reviews integrative, systems-oriented approaches to understanding mechanisms underlying infection, immune response and inflammation to find biomarkers of disease and design new drugs. We focus on the systems biology process, especially the data gathering and analysis techniques rather than the experimental technologies or latest computational resources. © 2011 Elsevier GmbH.

KW - Drug development

KW - Fungal diseases

KW - Host-pathogen interaction

KW - Infectious diseases

KW - Systems biology

U2 - 10.1016/j.imbio.2011.08.004

DO - 10.1016/j.imbio.2011.08.004

M3 - Article

C2 - 21889228

SN - 0171-2985

VL - 216

SP - 1212

EP - 1227

JO - Immunobiology

JF - Immunobiology

IS - 11

ER -

Systems biology of infectious diseases: A focus on fungal infections

Abstract

Keywords

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