SYSTEMS BIOLOGY: TOWARDS REALISTIC AND USEFUL MODELS OF MOLECULAR NETWORKS

H. V. Westerhoff; F. J. Bruggeman; A. Kolodkin; K. Rybakova; M. Mone; CM Bunce; MJ Campbell

doi:10.1007/978-90-481-3303-1_18

SYSTEMS BIOLOGY: TOWARDS REALISTIC AND USEFUL MODELS OF MOLECULAR NETWORKS

H. V. Westerhoff, F. J. Bruggeman, A. Kolodkin, K. Rybakova, M. Mone, CM Bunce (Editor), MJ Campbell (Editor)

Research output: Chapter in Book/Conference proceeding › Chapter

Abstract

Molecular biology is shifting focus from single molecules to networks of molecules. This development has changed our way of doing research and is challenging our thinking about cells. Cells turn out be complicated molecular systems displaying multivariate dynamics that can rarely be understood in terms of single molecules. One way to appreciate this complexity is to make mathematical models of signaling, gene, and metabolic network to assess the systemic consequences of specific molecular perturbations. This chapter gives a brief overview of some of the approach in mathematical modeling of molecular networks. We choose to keep the mathematical detail minimal and highlight a number of concepts and approaches that are emerging in the analysis of molecular networks.

Original language	English
Title of host publication	Nuclear Receptors
Subtitle of host publication	Current Concepts and Future Challenges
Volume	8
DOIs	https://doi.org/10.1007/978-90-481-3303-1_18
Publication status	Published - 2010

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title = "SYSTEMS BIOLOGY: TOWARDS REALISTIC AND USEFUL MODELS OF MOLECULAR NETWORKS",

abstract = "Molecular biology is shifting focus from single molecules to networks of molecules. This development has changed our way of doing research and is challenging our thinking about cells. Cells turn out be complicated molecular systems displaying multivariate dynamics that can rarely be understood in terms of single molecules. One way to appreciate this complexity is to make mathematical models of signaling, gene, and metabolic network to assess the systemic consequences of specific molecular perturbations. This chapter gives a brief overview of some of the approach in mathematical modeling of molecular networks. We choose to keep the mathematical detail minimal and highlight a number of concepts and approaches that are emerging in the analysis of molecular networks.",

author = "Westerhoff, {H. V.} and Bruggeman, {F. J.} and A. Kolodkin and K. Rybakova and M. Mone and CM Bunce and MJ Campbell",

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T1 - SYSTEMS BIOLOGY: TOWARDS REALISTIC AND USEFUL MODELS OF MOLECULAR NETWORKS

AU - Westerhoff, H. V.

AU - Bruggeman, F. J.

AU - Kolodkin, A.

AU - Rybakova, K.

AU - Mone, M.

A2 - Bunce, CM

A2 - Campbell, MJ

PY - 2010

Y1 - 2010

N2 - Molecular biology is shifting focus from single molecules to networks of molecules. This development has changed our way of doing research and is challenging our thinking about cells. Cells turn out be complicated molecular systems displaying multivariate dynamics that can rarely be understood in terms of single molecules. One way to appreciate this complexity is to make mathematical models of signaling, gene, and metabolic network to assess the systemic consequences of specific molecular perturbations. This chapter gives a brief overview of some of the approach in mathematical modeling of molecular networks. We choose to keep the mathematical detail minimal and highlight a number of concepts and approaches that are emerging in the analysis of molecular networks.

AB - Molecular biology is shifting focus from single molecules to networks of molecules. This development has changed our way of doing research and is challenging our thinking about cells. Cells turn out be complicated molecular systems displaying multivariate dynamics that can rarely be understood in terms of single molecules. One way to appreciate this complexity is to make mathematical models of signaling, gene, and metabolic network to assess the systemic consequences of specific molecular perturbations. This chapter gives a brief overview of some of the approach in mathematical modeling of molecular networks. We choose to keep the mathematical detail minimal and highlight a number of concepts and approaches that are emerging in the analysis of molecular networks.

U2 - 10.1007/978-90-481-3303-1_18

DO - 10.1007/978-90-481-3303-1_18

M3 - Chapter

SN - 978-90-481-3302-4(H)

VL - 8

BT - Nuclear Receptors

ER -

SYSTEMS BIOLOGY: TOWARDS REALISTIC AND USEFUL MODELS OF MOLECULAR NETWORKS

Abstract

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