T1 histograms of normal-appearing brain tissue are abnormal in early relapsing-remitting multiple sclerosis

C. M. Griffin; J. Dehmeshki; D. T. Chard; G. J M Parker; G. J. Barker; A. J. Thompson; D. H. Miller

doi:10.1191/1352458502ms807oa

T1 histograms of normal-appearing brain tissue are abnormal in early relapsing-remitting multiple sclerosis

C. M. Griffin, J. Dehmeshki, D. T. Chard, G. J M Parker, G. J. Barker, A. J. Thompson, D. H. Miller

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To use both whole-brain and normal-appearing brain tissue (NABT) T1 relaxation time histograms to investigate abnormalities in early relapsing-remitting (RR) multiple sclerosis (MS). Background: In patients with established MS, both lesions and NABT exhibit an increase in T1 relaxation time. By using T1 histogram analysis, it is hoped that such changes in early disease can be detected. Method: Twenty-seven patients and 14 age- and sex-matched controls underwent magnetic resonance imaging (MRI) of the brain, which included the following sequences: 1) proton density (PD)- and T2-weighted fast spin echo (FSE) to measure T2 lesion load, 2) PD- and T1-weighted gradient echos from which T1 relaxation was calculated, and 3) T1-weighted SE imaging pre- and post-triple dose (0.3 mmol/kg) gadolinium (Gd-DTPA) to measure T1 hypointense and gadolinium-enhancing lesion loads, respectively. All patients had RR MS with disease duration

Original language	English
Pages (from-to)	211-216
Number of pages	5
Journal	Multiple Sclerosis
Volume	8
Issue number	3
DOIs	https://doi.org/10.1191/1352458502ms807oa
Publication status	Published - 2002

Keywords

Early relapsing-remitting multiple sclerosis
Histograms
T1 relaxation time measurements

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10.1191/1352458502ms807oa

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@article{cc858675b6444b569b7174eb9ed43667,

title = "T1 histograms of normal-appearing brain tissue are abnormal in early relapsing-remitting multiple sclerosis",

abstract = "Objective: To use both whole-brain and normal-appearing brain tissue (NABT) T1 relaxation time histograms to investigate abnormalities in early relapsing-remitting (RR) multiple sclerosis (MS). Background: In patients with established MS, both lesions and NABT exhibit an increase in T1 relaxation time. By using T1 histogram analysis, it is hoped that such changes in early disease can be detected. Method: Twenty-seven patients and 14 age- and sex-matched controls underwent magnetic resonance imaging (MRI) of the brain, which included the following sequences: 1) proton density (PD)- and T2-weighted fast spin echo (FSE) to measure T2 lesion load, 2) PD- and T1-weighted gradient echos from which T1 relaxation was calculated, and 3) T1-weighted SE imaging pre- and post-triple dose (0.3 mmol/kg) gadolinium (Gd-DTPA) to measure T1 hypointense and gadolinium-enhancing lesion loads, respectively. All patients had RR MS with disease duration",

keywords = "Early relapsing-remitting multiple sclerosis, Histograms, T1 relaxation time measurements",

author = "Griffin, {C. M.} and J. Dehmeshki and Chard, {D. T.} and Parker, {G. J M} and Barker, {G. J.} and Thompson, {A. J.} and Miller, {D. H.}",

year = "2002",

doi = "10.1191/1352458502ms807oa",

language = "English",

volume = "8",

pages = "211--216",

journal = "Multiple Sclerosis",

issn = "1477-0970",

publisher = "Sage Publications Ltd",

number = "3",

}

TY - JOUR

T1 - T1 histograms of normal-appearing brain tissue are abnormal in early relapsing-remitting multiple sclerosis

AU - Griffin, C. M.

AU - Dehmeshki, J.

AU - Chard, D. T.

AU - Parker, G. J M

AU - Barker, G. J.

AU - Thompson, A. J.

AU - Miller, D. H.

PY - 2002

Y1 - 2002

N2 - Objective: To use both whole-brain and normal-appearing brain tissue (NABT) T1 relaxation time histograms to investigate abnormalities in early relapsing-remitting (RR) multiple sclerosis (MS). Background: In patients with established MS, both lesions and NABT exhibit an increase in T1 relaxation time. By using T1 histogram analysis, it is hoped that such changes in early disease can be detected. Method: Twenty-seven patients and 14 age- and sex-matched controls underwent magnetic resonance imaging (MRI) of the brain, which included the following sequences: 1) proton density (PD)- and T2-weighted fast spin echo (FSE) to measure T2 lesion load, 2) PD- and T1-weighted gradient echos from which T1 relaxation was calculated, and 3) T1-weighted SE imaging pre- and post-triple dose (0.3 mmol/kg) gadolinium (Gd-DTPA) to measure T1 hypointense and gadolinium-enhancing lesion loads, respectively. All patients had RR MS with disease duration

AB - Objective: To use both whole-brain and normal-appearing brain tissue (NABT) T1 relaxation time histograms to investigate abnormalities in early relapsing-remitting (RR) multiple sclerosis (MS). Background: In patients with established MS, both lesions and NABT exhibit an increase in T1 relaxation time. By using T1 histogram analysis, it is hoped that such changes in early disease can be detected. Method: Twenty-seven patients and 14 age- and sex-matched controls underwent magnetic resonance imaging (MRI) of the brain, which included the following sequences: 1) proton density (PD)- and T2-weighted fast spin echo (FSE) to measure T2 lesion load, 2) PD- and T1-weighted gradient echos from which T1 relaxation was calculated, and 3) T1-weighted SE imaging pre- and post-triple dose (0.3 mmol/kg) gadolinium (Gd-DTPA) to measure T1 hypointense and gadolinium-enhancing lesion loads, respectively. All patients had RR MS with disease duration

KW - Early relapsing-remitting multiple sclerosis

KW - Histograms

KW - T1 relaxation time measurements

U2 - 10.1191/1352458502ms807oa

DO - 10.1191/1352458502ms807oa

M3 - Article

SN - 1477-0970

VL - 8

SP - 211

EP - 216

JO - Multiple Sclerosis

JF - Multiple Sclerosis

IS - 3

ER -

T1 histograms of normal-appearing brain tissue are abnormal in early relapsing-remitting multiple sclerosis

Abstract

Keywords

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