T107. Neurological Predictors of Symptom Trajectories During and Following Treatment of Adolescents With a Primary Diagnosis of Major Depression

Sian Davies; Sharon Neufeld; Eleonore van Sprang; Lizanne Schweren; Rogier Keivit; Peter Fonagy; Bernadka Dubicka; Raphael Kelvin; Nicolas Midgley; Shirley Reynolds; Mary Target; Paul Wilkinson; Anne-Laura van Harmelen; John Suckling; Ian M. Goodyer

doi:10.1016/j.biopsych.2019.03.430

T107. Neurological Predictors of Symptom Trajectories During and Following Treatment of Adolescents With a Primary Diagnosis of Major Depression

Sian Davies, Sharon Neufeld, Eleonore van Sprang, Lizanne Schweren, Rogier Keivit, Peter Fonagy, Bernadka Dubicka, Raphael Kelvin, Nicolas Midgley, Shirley Reynolds, Mary Target, Paul Wilkinson, Anne-Laura van Harmelen, John Suckling, Ian M. Goodyer

Research output: Contribution to journal › Article › peer-review

Abstract

Structural abnormalities in the anterior cingulate, orbitofrontal, prefrontal and insula regions are associated with treatment non-response. These observations are not consistent in depressed adolescents. Definitions of treatment non-response are non-standardised and arbitrary, contributing to variations across studies. We aimed to classify depressed adolescents into different trajectories of symptomatic change using a data-driven approach; and conduct a preliminary investigation of structural brain predictors of class membership.

Original language	English
Journal	Biological Psychiatry
DOIs	https://doi.org/10.1016/j.biopsych.2019.03.430
Publication status	Published - 30 May 2019

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Davies, S., Neufeld, S., Sprang, E. V., Schweren, L., Keivit, R., Fonagy, P., Dubicka, B., Kelvin, R., Midgley, N., Reynolds, S., Target, M., Wilkinson, P., Harmelen, A.-L. V., Suckling, J., & Goodyer, I. M. (2019). T107. Neurological Predictors of Symptom Trajectories During and Following Treatment of Adolescents With a Primary Diagnosis of Major Depression. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2019.03.430

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title = "T107. Neurological Predictors of Symptom Trajectories During and Following Treatment of Adolescents With a Primary Diagnosis of Major Depression",

abstract = "Structural abnormalities in the anterior cingulate, orbitofrontal, prefrontal and insula regions are associated with treatment non-response. These observations are not consistent in depressed adolescents. Definitions of treatment non-response are non-standardised and arbitrary, contributing to variations across studies. We aimed to classify depressed adolescents into different trajectories of symptomatic change using a data-driven approach; and conduct a preliminary investigation of structural brain predictors of class membership.",

author = "Sian Davies and Sharon Neufeld and Sprang, {Eleonore van} and Lizanne Schweren and Rogier Keivit and Peter Fonagy and Bernadka Dubicka and Raphael Kelvin and Nicolas Midgley and Shirley Reynolds and Mary Target and Paul Wilkinson and Harmelen, {Anne-Laura van} and John Suckling and Goodyer, {Ian M.}",

year = "2019",

month = may,

day = "30",

doi = "10.1016/j.biopsych.2019.03.430",

language = "English",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier BV",

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Davies, S, Neufeld, S, Sprang, EV, Schweren, L, Keivit, R, Fonagy, P, Dubicka, B, Kelvin, R, Midgley, N, Reynolds, S, Target, M, Wilkinson, P, Harmelen, A-LV, Suckling, J & Goodyer, IM 2019, 'T107. Neurological Predictors of Symptom Trajectories During and Following Treatment of Adolescents With a Primary Diagnosis of Major Depression', Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2019.03.430

TY - JOUR

T1 - T107. Neurological Predictors of Symptom Trajectories During and Following Treatment of Adolescents With a Primary Diagnosis of Major Depression

AU - Davies, Sian

AU - Neufeld, Sharon

AU - Sprang, Eleonore van

AU - Schweren, Lizanne

AU - Keivit, Rogier

AU - Fonagy, Peter

AU - Dubicka, Bernadka

AU - Kelvin, Raphael

AU - Midgley, Nicolas

AU - Reynolds, Shirley

AU - Target, Mary

AU - Wilkinson, Paul

AU - Harmelen, Anne-Laura van

AU - Suckling, John

AU - Goodyer, Ian M.

PY - 2019/5/30

Y1 - 2019/5/30

N2 - Structural abnormalities in the anterior cingulate, orbitofrontal, prefrontal and insula regions are associated with treatment non-response. These observations are not consistent in depressed adolescents. Definitions of treatment non-response are non-standardised and arbitrary, contributing to variations across studies. We aimed to classify depressed adolescents into different trajectories of symptomatic change using a data-driven approach; and conduct a preliminary investigation of structural brain predictors of class membership.

AB - Structural abnormalities in the anterior cingulate, orbitofrontal, prefrontal and insula regions are associated with treatment non-response. These observations are not consistent in depressed adolescents. Definitions of treatment non-response are non-standardised and arbitrary, contributing to variations across studies. We aimed to classify depressed adolescents into different trajectories of symptomatic change using a data-driven approach; and conduct a preliminary investigation of structural brain predictors of class membership.

U2 - 10.1016/j.biopsych.2019.03.430

DO - 10.1016/j.biopsych.2019.03.430

M3 - Article

SN - 0006-3223

JO - Biological Psychiatry

JF - Biological Psychiatry

ER -

T107. Neurological Predictors of Symptom Trajectories During and Following Treatment of Adolescents With a Primary Diagnosis of Major Depression

Abstract

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