t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma

James A L Fenton; Ed Schuuring; Sharon L Barrans; Alison H Banham; Sara J Rollinson; Gareth J Morgan; Andrew S Jack; J Han J M van Krieken; Philip M Kluin

doi:10.1002/gcc.20278

t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma

James A L Fenton, Ed Schuuring, Sharon L Barrans, Alison H Banham, Sara J Rollinson, Gareth J Morgan, Andrew S Jack, J Han J M van Krieken, Philip M Kluin

University of Leeds

Research output: Contribution to journal › Article › peer-review

Abstract

Strong expression of Forkhead box-P1 (FOXP1), a winged-helix transcription factor, has been identified as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers.

Original language	English
Pages (from-to)	164-8
Number of pages	5
Journal	Genes, Chromosomes & Cancer
Volume	45
Issue number	2
DOIs	https://doi.org/10.1002/gcc.20278
Publication status	Published - Feb 2006

Keywords

Base Sequence
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 3
DNA Primers
Forkhead Transcription Factors
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lymphoma, B-Cell
Lymphoma, Large B-Cell, Diffuse
Repressor Proteins
Translocation, Genetic
Case Reports
Journal Article
Research Support, Non-U.S. Gov't

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10.1002/gcc.20278

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title = "t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma",

abstract = "Strong expression of Forkhead box-P1 (FOXP1), a winged-helix transcription factor, has been identified as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers.",

keywords = "Base Sequence, Chromosomes, Human, Pair 14, Chromosomes, Human, Pair 3, DNA Primers, Forkhead Transcription Factors, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Repressor Proteins, Translocation, Genetic, Case Reports, Journal Article, Research Support, Non-U.S. Gov't",

author = "Fenton, {James A L} and Ed Schuuring and Barrans, {Sharon L} and Banham, {Alison H} and Rollinson, {Sara J} and Morgan, {Gareth J} and Jack, {Andrew S} and {van Krieken}, {J Han J M} and Kluin, {Philip M}",

year = "2006",

month = feb,

doi = "10.1002/gcc.20278",

language = "English",

volume = "45",

pages = "164--8",

journal = "Genes Chromosomes and Cancer",

issn = "1045-2257",

publisher = "John Wiley & Sons Ltd",

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TY - JOUR

T1 - t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma

AU - Fenton, James A L

AU - Schuuring, Ed

AU - Barrans, Sharon L

AU - Banham, Alison H

AU - Rollinson, Sara J

AU - Morgan, Gareth J

AU - Jack, Andrew S

AU - van Krieken, J Han J M

AU - Kluin, Philip M

PY - 2006/2

Y1 - 2006/2

N2 - Strong expression of Forkhead box-P1 (FOXP1), a winged-helix transcription factor, has been identified as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers.

AB - Strong expression of Forkhead box-P1 (FOXP1), a winged-helix transcription factor, has been identified as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers.

KW - Base Sequence

KW - Chromosomes, Human, Pair 14

KW - Chromosomes, Human, Pair 3

KW - DNA Primers

KW - Forkhead Transcription Factors

KW - Humans

KW - Immunohistochemistry

KW - In Situ Hybridization, Fluorescence

KW - Lymphoma, B-Cell

KW - Lymphoma, Large B-Cell, Diffuse

KW - Repressor Proteins

KW - Translocation, Genetic

KW - Case Reports

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/gcc.20278

DO - 10.1002/gcc.20278

M3 - Article

C2 - 16252263

VL - 45

SP - 164

EP - 168

JO - Genes Chromosomes and Cancer

JF - Genes Chromosomes and Cancer

SN - 1045-2257

IS - 2

ER -

t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma

Abstract

Keywords

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