t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma

James A L Fenton, Ed Schuuring, Sharon L Barrans, Alison H Banham, Sara J Rollinson, Gareth J Morgan, Andrew S Jack, J Han J M van Krieken, Philip M Kluin

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Strong expression of Forkhead box-P1 (FOXP1), a winged-helix transcription factor, has been identified as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers.

    Original languageEnglish
    Pages (from-to)164-8
    Number of pages5
    JournalGenes, Chromosomes & Cancer
    Volume45
    Issue number2
    DOIs
    Publication statusPublished - Feb 2006

    Keywords

    • Base Sequence
    • Chromosomes, Human, Pair 14
    • Chromosomes, Human, Pair 3
    • DNA Primers
    • Forkhead Transcription Factors
    • Humans
    • Immunohistochemistry
    • In Situ Hybridization, Fluorescence
    • Lymphoma, B-Cell
    • Lymphoma, Large B-Cell, Diffuse
    • Repressor Proteins
    • Translocation, Genetic
    • Case Reports
    • Journal Article
    • Research Support, Non-U.S. Gov't

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