Tacrolimus enhances the recovery of normal laryngeal muscle fibre distribution after reinnervation.

P Gorphe, N Guerout, M Birchall, G Terenghi, J-P Marie

    Research output: Contribution to journalArticlepeer-review

    Abstract

    OBJECTIVES: To assess the recovery of various muscle fibre types in the posterior cricoarytenoid muscle after laryngeal reinnervation in the rat, and to determine the influence of tacrolimus on this process. METHODS: Four groups of rats underwent resection and anastomosis of the left vagus nerve, and were administered either tacrolimus at a low dose or an immunosuppressive dose, or cyclosporin A at a low dose or an immunosuppressive dose. A fifth group received surgery alone, and a sixth group received neither surgery nor drug treatment (healthy group). Muscles were removed for immunohistochemical analysis 45 days after surgery. RESULTS: There was no difference in the proportion of types 1, 2a and 2b muscle fibres, comparing the immunosuppressive tacrolimus group and the healthy group, whereas there were fewer type 1 fibres in the group receiving surgery alone, compared with the healthy group (7 vs 12.1 per cent, respectively; p = 0.0303). CONCLUSION: Tacrolimus enhanced the recovery of normal laryngeal muscle fibres after reinnervation in the rat, indicating a possible role in laryngeal transplantation.
    Original languageEnglish
    JournalThe Journal of laryngology and otology
    Volume126
    Issue number11
    DOIs
    Publication statusPublished - Nov 2012

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