Talin gets SHANKed in the fight for integrin activation

Paul Atherton; Christoph Ballestrem

doi:10.1038/ncb3501

Talin gets SHANKed in the fight for integrin activation

Paul Atherton, Christoph Ballestrem

Division of Cell Matrix Biology & Regenerative Medicine (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Genetic mutations in the SHANK family of proteins are linked to multiple neuropsychiatric disorders including autism spectrum disorders. A study now elucidates critical roles for SHANK in regulating integrin-mediated cell-extracellular matrix adhesion, by sequestering integrin activators.

Original language	English
Pages (from-to)	265-267
Number of pages	3
Journal	Nature Cell Biology
Volume	19
Issue number	4
DOIs	https://doi.org/10.1038/ncb3501
Publication status	Published - 31 Mar 2017

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title = "Talin gets SHANKed in the fight for integrin activation",

abstract = "Genetic mutations in the SHANK family of proteins are linked to multiple neuropsychiatric disorders including autism spectrum disorders. A study now elucidates critical roles for SHANK in regulating integrin-mediated cell-extracellular matrix adhesion, by sequestering integrin activators.",

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Talin gets SHANKed in the fight for integrin activation

Abstract

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