'TamiGold':: Phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)

M. Stanley; N. Cattle; J. McCauley; S.R. Martin; A. Rashid; R.A. Field; B. Carbain; H. Streicher

doi:10.1039/c2md20034a

'TamiGold': Phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)

M. Stanley, N. Cattle, J. McCauley, S.R. Martin, A. Rashid, R.A. Field, B. Carbain, H. Streicher

Manchester Institute of Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

The strong and selective binding of 2 types of gold nanoparticles that are decorated with the oseltamivir (aka TamifluTM) pharmacophore to wild-type and resistant influenza virus strains, including isolates from the 2009 pandemic, is reported. The particles interact with the virus neuraminidase rather than the hemagglutinin and could serve as a vantage point for novel influenza virus sensors, due to the intrinsic advantages of oseltamivir over the natural sialic acid ligand or even zanamivir.

Original language	Undefined
Pages (from-to)	1373-1376
Number of pages	4
Journal	MedChemComm
Volume	3
Issue number	11
DOIs	https://doi.org/10.1039/c2md20034a
Publication status	Published - 9 May 2012

Research Beacons, Institutes and Platforms

Manchester Institute of Biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c2md20034a

Cite this

@article{ed0c0c3c04a04e41bd799f9283fd4eb5,

title = "'TamiGold':: Phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)",

abstract = "The strong and selective binding of 2 types of gold nanoparticles that are decorated with the oseltamivir (aka TamifluTM) pharmacophore to wild-type and resistant influenza virus strains, including isolates from the 2009 pandemic, is reported. The particles interact with the virus neuraminidase rather than the hemagglutinin and could serve as a vantage point for novel influenza virus sensors, due to the intrinsic advantages of oseltamivir over the natural sialic acid ligand or even zanamivir.",

author = "M. Stanley and N. Cattle and J. McCauley and S.R. Martin and A. Rashid and R.A. Field and B. Carbain and H. Streicher",

year = "2012",

month = may,

day = "9",

doi = "10.1039/c2md20034a",

language = "Undefined",

volume = "3",

pages = "1373--1376",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "11",

}

TY - JOUR

T1 - 'TamiGold':

T2 - Phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)

AU - Stanley, M.

AU - Cattle, N.

AU - McCauley, J.

AU - Martin, S.R.

AU - Rashid, A.

AU - Field, R.A.

AU - Carbain, B.

AU - Streicher, H.

PY - 2012/5/9

Y1 - 2012/5/9

N2 - The strong and selective binding of 2 types of gold nanoparticles that are decorated with the oseltamivir (aka TamifluTM) pharmacophore to wild-type and resistant influenza virus strains, including isolates from the 2009 pandemic, is reported. The particles interact with the virus neuraminidase rather than the hemagglutinin and could serve as a vantage point for novel influenza virus sensors, due to the intrinsic advantages of oseltamivir over the natural sialic acid ligand or even zanamivir.

AB - The strong and selective binding of 2 types of gold nanoparticles that are decorated with the oseltamivir (aka TamifluTM) pharmacophore to wild-type and resistant influenza virus strains, including isolates from the 2009 pandemic, is reported. The particles interact with the virus neuraminidase rather than the hemagglutinin and could serve as a vantage point for novel influenza virus sensors, due to the intrinsic advantages of oseltamivir over the natural sialic acid ligand or even zanamivir.

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84867959633&partnerID=MN8TOARS

U2 - 10.1039/c2md20034a

DO - 10.1039/c2md20034a

M3 - Article

SN - 2040-2503

VL - 3

SP - 1373

EP - 1376

JO - MedChemComm

JF - MedChemComm

IS - 11

ER -