Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants

Junhui Zou; Yung Wei Pan; Zhenshan Wang; Shih Yu Chang; Wenbin Wang; Xin Wang; Cathy Tournier; Daniel R. Storm; Zhengui Xia

doi:10.1523/JNEUROSCI.6260-11.2012

Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants

Junhui Zou, Yung Wei Pan, Zhenshan Wang, Shih Yu Chang, Wenbin Wang, Xin Wang, Cathy Tournier, Daniel R. Storm, Zhengui Xia

Research output: Contribution to journal › Article › peer-review

Abstract

ERK5 MAP kinase is highly expressed in the developing nervous system and has been implicated in promoting the survival of immature neuronsinculture. However,itsroleinthedevelopmentandfunctionofthe mammaliannervous system has notbeen establishedin vivo. Here, we report that conditional deletion of the erk5 gene in mouse neural stem cells during development reduces the number of GABAergic interneurons in the main olfactory bulb (OB). Our data suggest that this is due to a decrease in proliferation and an increase inapoptosisinthesubventricularzoneandrostral migratorystreamofERK5 mutantmice.Interestingly, ERK5mutant micehavesmaller OB and are impaired in odor discrimination between structurally similar odorants. We conclude that ERK5 is a novel signaling pathway regulating developmental OB neurogenesis and olfactory behavior. © 2012 the authors.

Original language	English
Pages (from-to)	4118-4132
Number of pages	14
Journal	Journal of Neuroscience
Volume	32
Issue number	12
DOIs	https://doi.org/10.1523/JNEUROSCI.6260-11.2012
Publication status	Published - 21 Mar 2012

Access to Document

10.1523/JNEUROSCI.6260-11.2012

http://www.jneurosci.org/content/32/12/4118.full.pdf#page=1&view=FitH

Fingerprint

Dive into the research topics of 'Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants'. Together they form a unique fingerprint.

Cite this

Zou, J., Pan, Y. W., Wang, Z., Chang, S. Y., Wang, W., Wang, X., Tournier, C., Storm, D. R., & Xia, Z. (2012). Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants. Journal of Neuroscience, 32(12), 4118-4132. https://doi.org/10.1523/JNEUROSCI.6260-11.2012

@article{455ca7ff21b349e18e0730a8a7b2eb08,

title = "Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants",

abstract = "ERK5 MAP kinase is highly expressed in the developing nervous system and has been implicated in promoting the survival of immature neuronsinculture. However,itsroleinthedevelopmentandfunctionofthe mammaliannervous system has notbeen establishedin vivo. Here, we report that conditional deletion of the erk5 gene in mouse neural stem cells during development reduces the number of GABAergic interneurons in the main olfactory bulb (OB). Our data suggest that this is due to a decrease in proliferation and an increase inapoptosisinthesubventricularzoneandrostral migratorystreamofERK5 mutantmice.Interestingly, ERK5mutant micehavesmaller OB and are impaired in odor discrimination between structurally similar odorants. We conclude that ERK5 is a novel signaling pathway regulating developmental OB neurogenesis and olfactory behavior. {\textcopyright} 2012 the authors.",

author = "Junhui Zou and Pan, {Yung Wei} and Zhenshan Wang and Chang, {Shih Yu} and Wenbin Wang and Xin Wang and Cathy Tournier and Storm, {Daniel R.} and Zhengui Xia",

note = "AG19193, NIA NIH HHS, United StatesDC004156, NIDCD NIH HHS, United StatesF31 DC011216-02, NIDCD NIH HHS, United StatesF31DC011216, NIDCD NIH HHS, United StatesP30 HD02274, NICHD NIH HHS, United StatesR01 AG019193-09, NIA NIH HHS, United StatesR01 DC004156, NIDCD NIH HHS, United StatesR01 DC004156-14, NIDCD NIH HHS, United StatesT32HD007183, NICHD NIH HHS, United States",

year = "2012",

month = mar,

day = "21",

doi = "10.1523/JNEUROSCI.6260-11.2012",

language = "English",

volume = "32",

pages = "4118--4132",

journal = "Journal of Neuroscience",

issn = "0270-6474",

publisher = "Society for Neuroscience",

number = "12",

}

Zou, J, Pan, YW, Wang, Z, Chang, SY, Wang, W, Wang, X , Tournier, C, Storm, DR & Xia, Z 2012, 'Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants', Journal of Neuroscience, vol. 32, no. 12, pp. 4118-4132. https://doi.org/10.1523/JNEUROSCI.6260-11.2012

Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants. / Zou, Junhui; Pan, Yung Wei; Wang, Zhenshan et al.
In: Journal of Neuroscience, Vol. 32, No. 12, 21.03.2012, p. 4118-4132.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants

AU - Zou, Junhui

AU - Pan, Yung Wei

AU - Wang, Zhenshan

AU - Chang, Shih Yu

AU - Wang, Wenbin

AU - Wang, Xin

AU - Tournier, Cathy

AU - Storm, Daniel R.

AU - Xia, Zhengui

N1 - AG19193, NIA NIH HHS, United StatesDC004156, NIDCD NIH HHS, United StatesF31 DC011216-02, NIDCD NIH HHS, United StatesF31DC011216, NIDCD NIH HHS, United StatesP30 HD02274, NICHD NIH HHS, United StatesR01 AG019193-09, NIA NIH HHS, United StatesR01 DC004156, NIDCD NIH HHS, United StatesR01 DC004156-14, NIDCD NIH HHS, United StatesT32HD007183, NICHD NIH HHS, United States

PY - 2012/3/21

Y1 - 2012/3/21

N2 - ERK5 MAP kinase is highly expressed in the developing nervous system and has been implicated in promoting the survival of immature neuronsinculture. However,itsroleinthedevelopmentandfunctionofthe mammaliannervous system has notbeen establishedin vivo. Here, we report that conditional deletion of the erk5 gene in mouse neural stem cells during development reduces the number of GABAergic interneurons in the main olfactory bulb (OB). Our data suggest that this is due to a decrease in proliferation and an increase inapoptosisinthesubventricularzoneandrostral migratorystreamofERK5 mutantmice.Interestingly, ERK5mutant micehavesmaller OB and are impaired in odor discrimination between structurally similar odorants. We conclude that ERK5 is a novel signaling pathway regulating developmental OB neurogenesis and olfactory behavior. © 2012 the authors.

AB - ERK5 MAP kinase is highly expressed in the developing nervous system and has been implicated in promoting the survival of immature neuronsinculture. However,itsroleinthedevelopmentandfunctionofthe mammaliannervous system has notbeen establishedin vivo. Here, we report that conditional deletion of the erk5 gene in mouse neural stem cells during development reduces the number of GABAergic interneurons in the main olfactory bulb (OB). Our data suggest that this is due to a decrease in proliferation and an increase inapoptosisinthesubventricularzoneandrostral migratorystreamofERK5 mutantmice.Interestingly, ERK5mutant micehavesmaller OB and are impaired in odor discrimination between structurally similar odorants. We conclude that ERK5 is a novel signaling pathway regulating developmental OB neurogenesis and olfactory behavior. © 2012 the authors.

U2 - 10.1523/JNEUROSCI.6260-11.2012

DO - 10.1523/JNEUROSCI.6260-11.2012

M3 - Article

C2 - 22442076

SN - 0270-6474

VL - 32

SP - 4118

EP - 4132

JO - Journal of Neuroscience

JF - Journal of Neuroscience

IS - 12

ER -