Targeting gene expression to hypoxic tumor cells

Gabi U. Dachs, Adam V. Patterson, John D. Firth, Peter J. Ratcliffe, K. M. Stuart Townsend, Ian J. Stratford, Adrian L. Harris

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Solid tumors with areas of low oxygen tension (hypoxia) have a poor prognosis, as cells in this environment often survive radiation and chemotherapy. In this report we describe how this hypoxic environment can be used to activate heterologous gene expression driven by a hypoxia-responsive element (HRE), which interacts with the transcriptional complex hypoxia-inducible factor-1 (HIF-1). Our results demonstrate that the HIF-1/HRE system of gene regulation is active in hypoxic tumor cells and show the potential of exploiting tumor-specific conditions for the targeted expression of diagnostic or therapeutic genes in cancer therapy.
    Original languageEnglish
    Pages (from-to)515-520
    Number of pages5
    JournalNature Medicine
    Volume3
    Issue number5
    Publication statusPublished - 1997

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