Targeting gene expression to hypoxic tumor cells

Gabi U. Dachs; Adam V. Patterson; John D. Firth; Peter J. Ratcliffe; K. M. Stuart Townsend; Ian J. Stratford; Adrian L. Harris

Targeting gene expression to hypoxic tumor cells

Gabi U. Dachs, Adam V. Patterson, John D. Firth, Peter J. Ratcliffe, K. M. Stuart Townsend, Ian J. Stratford, Adrian L. Harris

Research output: Contribution to journal › Article › peer-review

Abstract

Solid tumors with areas of low oxygen tension (hypoxia) have a poor prognosis, as cells in this environment often survive radiation and chemotherapy. In this report we describe how this hypoxic environment can be used to activate heterologous gene expression driven by a hypoxia-responsive element (HRE), which interacts with the transcriptional complex hypoxia-inducible factor-1 (HIF-1). Our results demonstrate that the HIF-1/HRE system of gene regulation is active in hypoxic tumor cells and show the potential of exploiting tumor-specific conditions for the targeted expression of diagnostic or therapeutic genes in cancer therapy.

Original language	English
Pages (from-to)	515-520
Number of pages	5
Journal	Nature Medicine
Volume	3
Issue number	5
Publication status	Published - 1997

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title = "Targeting gene expression to hypoxic tumor cells",

abstract = "Solid tumors with areas of low oxygen tension (hypoxia) have a poor prognosis, as cells in this environment often survive radiation and chemotherapy. In this report we describe how this hypoxic environment can be used to activate heterologous gene expression driven by a hypoxia-responsive element (HRE), which interacts with the transcriptional complex hypoxia-inducible factor-1 (HIF-1). Our results demonstrate that the HIF-1/HRE system of gene regulation is active in hypoxic tumor cells and show the potential of exploiting tumor-specific conditions for the targeted expression of diagnostic or therapeutic genes in cancer therapy.",

author = "Dachs, {Gabi U.} and Patterson, {Adam V.} and Firth, {John D.} and Ratcliffe, {Peter J.} and {Stuart Townsend}, {K. M.} and Stratford, {Ian J.} and Harris, {Adrian L.}",

year = "1997",

language = "English",

volume = "3",

pages = "515--520",

journal = "Nature Medicine",

issn = "1078-8956",

publisher = "Nature Research",

number = "5",

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TY - JOUR

T1 - Targeting gene expression to hypoxic tumor cells

AU - Dachs, Gabi U.

AU - Patterson, Adam V.

AU - Firth, John D.

AU - Ratcliffe, Peter J.

AU - Stuart Townsend, K. M.

AU - Stratford, Ian J.

AU - Harris, Adrian L.

PY - 1997

Y1 - 1997

N2 - Solid tumors with areas of low oxygen tension (hypoxia) have a poor prognosis, as cells in this environment often survive radiation and chemotherapy. In this report we describe how this hypoxic environment can be used to activate heterologous gene expression driven by a hypoxia-responsive element (HRE), which interacts with the transcriptional complex hypoxia-inducible factor-1 (HIF-1). Our results demonstrate that the HIF-1/HRE system of gene regulation is active in hypoxic tumor cells and show the potential of exploiting tumor-specific conditions for the targeted expression of diagnostic or therapeutic genes in cancer therapy.

AB - Solid tumors with areas of low oxygen tension (hypoxia) have a poor prognosis, as cells in this environment often survive radiation and chemotherapy. In this report we describe how this hypoxic environment can be used to activate heterologous gene expression driven by a hypoxia-responsive element (HRE), which interacts with the transcriptional complex hypoxia-inducible factor-1 (HIF-1). Our results demonstrate that the HIF-1/HRE system of gene regulation is active in hypoxic tumor cells and show the potential of exploiting tumor-specific conditions for the targeted expression of diagnostic or therapeutic genes in cancer therapy.

M3 - Article

SN - 1078-8956

VL - 3

SP - 515

EP - 520

JO - Nature Medicine

JF - Nature Medicine

IS - 5

ER -

Targeting gene expression to hypoxic tumor cells

Abstract

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