Abstract
There is a critical need for novel therapies to treat patients with advanced biliary tract cancer (BTC). This systematic review summarizes the evidence-based knowledge for the potential role of PD-1 and PD-L1 monoclonal antibodies in the treatment of patients with early-stage and advanced BTC. An Embase database search was conducted, identifying 15 eligible phase II/III clinical trials for review. Results from recent phase III trials show a statistically significant overall survival (OS) benefit from the addition of PD-1/PD-L1 inhibitors to chemotherapy in the first-line management of advanced BTC. Future research should concentrate on the discovery of biomarkers to identify patients who would benefit most from these therapies.
Original language | English |
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Pages (from-to) | 517-530 |
Number of pages | 14 |
Journal | Immunotherapy |
Volume | 15 |
Issue number | 7 |
Early online date | 3 Apr 2023 |
DOIs | |
Publication status | Published - 1 May 2023 |
Keywords
- Biliary tract cancer
- cholangiocarcinoma
- immunotherapy
- PD-1 inhibitor
- PD-L1 inhibitor
- biliary tract cancer