Targeting the lung using siRNA and antisense based oligonucleotides

Sterghios A. Moschos, Karen Spinks, Andrew E. Williams, Mark A. Lindsay

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The accessibility to topical administration through inhalation, combined with its large surface area, has led to speculation that the lung might offer an ideal target for the application of oligonucleotide based therapeutics. In this review, we shall critically examine the challenges facing antisense and siRNA based approaches for target validation in viva and as potential therapeutics. In particular, we shall discuss the antisense and siRNA based approaches in relation to factors such as delivery, distribution, stability, off-target effects, unwanted immune responses and the selection of the optimum mRNA targets. © 2008 Bentham Science Publishers Ltd.
    Original languageEnglish
    Pages (from-to)3620-3627
    Number of pages7
    JournalCurrent Pharmaceutical Design
    Volume14
    Issue number34
    DOIs
    Publication statusPublished - 2008

    Keywords

    • Airways
    • Antisense
    • Lung
    • RNA interference
    • SiRNA

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