Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001

S. Krishnan; R. Wade; A. V. Moorman; C. Mitchell; S. E. Kinsey; T. O B Eden; C. Parker; A. Vora; S. Richards; V. Saha

doi:10.1038/leu.2009.264

Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001

S. Krishnan, R. Wade, A. V. Moorman, C. Mitchell, S. E. Kinsey, T. O B Eden, C. Parker, A. Vora, S. Richards, V. Saha

Research output: Contribution to journal › Article › peer-review

Abstract

Despite the success of contemporary treatment protocols in childhood acute lymphoblastic leukaemia (ALL), relapse within the central nervous system (CNS) remains a challenge. To better understand this phenomenon, we have analysed the changes in incidence and pattern of CNS relapses in 5564 children enrolled in four successive Medical Research Council-ALL trials between 1985 and 2001. Changes in the incidence and pattern of CNS relapses were examined and the relationship with patient characteristics was assessed. The factors affecting outcome after relapse were determined. Overall, relapses declined by 49%. Decreases occurred primarily in non-CNS and combined relapses with a progressive shift towards later (≥30 months from diagnosis) relapses (P

Original language	English
Pages (from-to)	450-459
Number of pages	9
Journal	Leukemia
Volume	24
Issue number	2
DOIs	https://doi.org/10.1038/leu.2009.264
Publication status	Published - Feb 2010

Keywords

Childhood acute lymphoblastic leukaemia
CNS
Relapse
United Kingdom

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/leu.2009.264

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Krishnan, S., Wade, R., Moorman, A. V., Mitchell, C., Kinsey, S. E., Eden, T. O. B., Parker, C., Vora, A., Richards, S., & Saha, V. (2010). Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001. Leukemia, 24(2), 450-459. https://doi.org/10.1038/leu.2009.264

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title = "Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001",

abstract = "Despite the success of contemporary treatment protocols in childhood acute lymphoblastic leukaemia (ALL), relapse within the central nervous system (CNS) remains a challenge. To better understand this phenomenon, we have analysed the changes in incidence and pattern of CNS relapses in 5564 children enrolled in four successive Medical Research Council-ALL trials between 1985 and 2001. Changes in the incidence and pattern of CNS relapses were examined and the relationship with patient characteristics was assessed. The factors affecting outcome after relapse were determined. Overall, relapses declined by 49%. Decreases occurred primarily in non-CNS and combined relapses with a progressive shift towards later (≥30 months from diagnosis) relapses (P",

keywords = "Childhood acute lymphoblastic leukaemia, CNS, Relapse, United Kingdom",

author = "S. Krishnan and R. Wade and Moorman, {A. V.} and C. Mitchell and Kinsey, {S. E.} and Eden, {T. O B} and C. Parker and A. Vora and S. Richards and V. Saha",

note = ", Cancer Research UK, United Kingdom, Medical Research Council, United Kingdom",

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Krishnan, S, Wade, R, Moorman, AV, Mitchell, C, Kinsey, SE, Eden, TOB, Parker, C, Vora, A, Richards, S & Saha, V 2010, 'Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001', Leukemia, vol. 24, no. 2, pp. 450-459. https://doi.org/10.1038/leu.2009.264

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T1 - Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001

AU - Krishnan, S.

AU - Wade, R.

AU - Moorman, A. V.

AU - Mitchell, C.

AU - Kinsey, S. E.

AU - Eden, T. O B

AU - Parker, C.

AU - Vora, A.

AU - Richards, S.

AU - Saha, V.

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PY - 2010/2

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N2 - Despite the success of contemporary treatment protocols in childhood acute lymphoblastic leukaemia (ALL), relapse within the central nervous system (CNS) remains a challenge. To better understand this phenomenon, we have analysed the changes in incidence and pattern of CNS relapses in 5564 children enrolled in four successive Medical Research Council-ALL trials between 1985 and 2001. Changes in the incidence and pattern of CNS relapses were examined and the relationship with patient characteristics was assessed. The factors affecting outcome after relapse were determined. Overall, relapses declined by 49%. Decreases occurred primarily in non-CNS and combined relapses with a progressive shift towards later (≥30 months from diagnosis) relapses (P

AB - Despite the success of contemporary treatment protocols in childhood acute lymphoblastic leukaemia (ALL), relapse within the central nervous system (CNS) remains a challenge. To better understand this phenomenon, we have analysed the changes in incidence and pattern of CNS relapses in 5564 children enrolled in four successive Medical Research Council-ALL trials between 1985 and 2001. Changes in the incidence and pattern of CNS relapses were examined and the relationship with patient characteristics was assessed. The factors affecting outcome after relapse were determined. Overall, relapses declined by 49%. Decreases occurred primarily in non-CNS and combined relapses with a progressive shift towards later (≥30 months from diagnosis) relapses (P

KW - Childhood acute lymphoblastic leukaemia

KW - CNS

KW - Relapse

KW - United Kingdom

U2 - 10.1038/leu.2009.264

DO - 10.1038/leu.2009.264

M3 - Article

C2 - 20016529

SN - 0887-6924

VL - 24

SP - 450

EP - 459

JO - Leukemia

JF - Leukemia

IS - 2

ER -

Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001

Abstract

Keywords

UN SDGs

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