Test liquids for quantitative MRI measurements of self-diffusion coefficient in vivo

Paul S. Tofts; D. Lloyd; C. A. Clark; G. J. Barker; G. J M Parker; P. McConville; C. Baldock; J. M. Pope

Test liquids for quantitative MRI measurements of self-diffusion coefficient in vivo

Paul S. Tofts, D. Lloyd, C. A. Clark, G. J. Barker, G. J M Parker, P. McConville, C. Baldock, J. M. Pope

Research output: Contribution to journal › Article › peer-review

Abstract

A range of liquids suitable as quality control test objects for measuring the accuracy of clinical MRI diffusion sequences (both apparent diffusion coefficient and tensor) has been identified and characterized. The self-diffusion coefficients for 15 liquids (3 cyclic alkanes: cyclohexane to cyclooctane, 9 n-alkanes: n-octane to n-hexadecane, and 3 n-alcohols: ethanol to 1-propanol) were measured at 15-30°C using an NMR spectrometer. Values at 22°C range from 0.36 to 2.2 10-9 m2s-1. Typical 95% confidence limits are ±2%. Temperature coefficients are 1.7-3.2 %/°C. T1 and T2 values at 1.5 T and proton density are given. n-tridecane has a diffusion coefficient close to that of normal white matter. The longer n-alkanes may be useful T2 standards. Measurements from a spin-echo MRI sequence agreed to within 2%. (C) 2000 Wiley-Liss, Inc.

Original language	English
Pages (from-to)	368-374
Number of pages	6
Journal	Magnetic Resonance in Medicine
Volume	43
Issue number	3
Publication status	Published - 2000

Keywords

Alkane
Diffusion coefficient
MRI
Quality control

Cite this

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title = "Test liquids for quantitative MRI measurements of self-diffusion coefficient in vivo",

abstract = "A range of liquids suitable as quality control test objects for measuring the accuracy of clinical MRI diffusion sequences (both apparent diffusion coefficient and tensor) has been identified and characterized. The self-diffusion coefficients for 15 liquids (3 cyclic alkanes: cyclohexane to cyclooctane, 9 n-alkanes: n-octane to n-hexadecane, and 3 n-alcohols: ethanol to 1-propanol) were measured at 15-30°C using an NMR spectrometer. Values at 22°C range from 0.36 to 2.2 10-9 m2s-1. Typical 95% confidence limits are ±2%. Temperature coefficients are 1.7-3.2 %/°C. T1 and T2 values at 1.5 T and proton density are given. n-tridecane has a diffusion coefficient close to that of normal white matter. The longer n-alkanes may be useful T2 standards. Measurements from a spin-echo MRI sequence agreed to within 2%. (C) 2000 Wiley-Liss, Inc.",

keywords = "Alkane, Diffusion coefficient, MRI, Quality control",

author = "Tofts, {Paul S.} and D. Lloyd and Clark, {C. A.} and Barker, {G. J.} and Parker, {G. J M} and P. McConville and C. Baldock and Pope, {J. M.}",

year = "2000",

language = "English",

volume = "43",

pages = "368--374",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "John Wiley & Sons Ltd",

number = "3",

}

TY - JOUR

T1 - Test liquids for quantitative MRI measurements of self-diffusion coefficient in vivo

AU - Tofts, Paul S.

AU - Lloyd, D.

AU - Clark, C. A.

AU - Barker, G. J.

AU - Parker, G. J M

AU - McConville, P.

AU - Baldock, C.

AU - Pope, J. M.

PY - 2000

Y1 - 2000

N2 - A range of liquids suitable as quality control test objects for measuring the accuracy of clinical MRI diffusion sequences (both apparent diffusion coefficient and tensor) has been identified and characterized. The self-diffusion coefficients for 15 liquids (3 cyclic alkanes: cyclohexane to cyclooctane, 9 n-alkanes: n-octane to n-hexadecane, and 3 n-alcohols: ethanol to 1-propanol) were measured at 15-30°C using an NMR spectrometer. Values at 22°C range from 0.36 to 2.2 10-9 m2s-1. Typical 95% confidence limits are ±2%. Temperature coefficients are 1.7-3.2 %/°C. T1 and T2 values at 1.5 T and proton density are given. n-tridecane has a diffusion coefficient close to that of normal white matter. The longer n-alkanes may be useful T2 standards. Measurements from a spin-echo MRI sequence agreed to within 2%. (C) 2000 Wiley-Liss, Inc.

AB - A range of liquids suitable as quality control test objects for measuring the accuracy of clinical MRI diffusion sequences (both apparent diffusion coefficient and tensor) has been identified and characterized. The self-diffusion coefficients for 15 liquids (3 cyclic alkanes: cyclohexane to cyclooctane, 9 n-alkanes: n-octane to n-hexadecane, and 3 n-alcohols: ethanol to 1-propanol) were measured at 15-30°C using an NMR spectrometer. Values at 22°C range from 0.36 to 2.2 10-9 m2s-1. Typical 95% confidence limits are ±2%. Temperature coefficients are 1.7-3.2 %/°C. T1 and T2 values at 1.5 T and proton density are given. n-tridecane has a diffusion coefficient close to that of normal white matter. The longer n-alkanes may be useful T2 standards. Measurements from a spin-echo MRI sequence agreed to within 2%. (C) 2000 Wiley-Liss, Inc.

KW - Alkane

KW - Diffusion coefficient

KW - MRI

KW - Quality control

M3 - Article

SN - 0740-3194

VL - 43

SP - 368

EP - 374

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 3

ER -

Test liquids for quantitative MRI measurements of self-diffusion coefficient in vivo

Abstract

Keywords

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