Testosterone in androgen receptor signaling and DNA repair: Enemy or frenemy?

Melvin Lee Kiang Chua; Robert G. Bristow

doi:10.1158/1078-0432.CCR-16-0381

Testosterone in androgen receptor signaling and DNA repair: Enemy or frenemy?

Melvin Lee Kiang Chua, Robert G. Bristow

Division of Cancer Sciences (L5)

University of Toronto

Research output: Contribution to journal › Article › peer-review

Abstract

Androgen suppression mediates transcriptional downregulation of DNA repair genes. Stimulation with supraphysiologic levels of dihydrotestosterone induces formation of lethal DNA breaks through recruitment of topoisomerase II enzymes to fragile DNA sites. Bipolar castration and stimulation that contributes to increasing DNA damage represents a novel strategy of sensitizing prostate cancer to cytotoxic therapies, including radiotherapy.

Original language	English
Pages (from-to)	3124-3126
Number of pages	3
Journal	Clinical Cancer Research
Volume	22
Issue number	13
DOIs	https://doi.org/10.1158/1078-0432.CCR-16-0381
Publication status	Published - 1 Jul 2016

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/1078-0432.CCR-16-0381

Cite this

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title = "Testosterone in androgen receptor signaling and DNA repair: Enemy or frenemy?",

abstract = "Androgen suppression mediates transcriptional downregulation of DNA repair genes. Stimulation with supraphysiologic levels of dihydrotestosterone induces formation of lethal DNA breaks through recruitment of topoisomerase II enzymes to fragile DNA sites. Bipolar castration and stimulation that contributes to increasing DNA damage represents a novel strategy of sensitizing prostate cancer to cytotoxic therapies, including radiotherapy.",

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AU - Bristow, Robert G.

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N2 - Androgen suppression mediates transcriptional downregulation of DNA repair genes. Stimulation with supraphysiologic levels of dihydrotestosterone induces formation of lethal DNA breaks through recruitment of topoisomerase II enzymes to fragile DNA sites. Bipolar castration and stimulation that contributes to increasing DNA damage represents a novel strategy of sensitizing prostate cancer to cytotoxic therapies, including radiotherapy.

AB - Androgen suppression mediates transcriptional downregulation of DNA repair genes. Stimulation with supraphysiologic levels of dihydrotestosterone induces formation of lethal DNA breaks through recruitment of topoisomerase II enzymes to fragile DNA sites. Bipolar castration and stimulation that contributes to increasing DNA damage represents a novel strategy of sensitizing prostate cancer to cytotoxic therapies, including radiotherapy.

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JO - Clinical Cancer Research

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Testosterone in androgen receptor signaling and DNA repair: Enemy or frenemy?

Abstract

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UN SDGs

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