TY - JOUR
T1 - TGFβ: A sleeping giant awoken by integrins
AU - Worthington, John J.
AU - Klementowicz, Joanna E.
AU - Travis, Mark A.
N1 - , Biotechnology and Biological Sciences Research Council, United Kingdom
PY - 2011/1
Y1 - 2011/1
N2 - Transforming growth factor beta (TGFβ) controls numerous cellular responses, including proliferation, differentiation, apoptosis and migration. This cytokine is produced by many different cell types and has been implicated in the pathogenesis of many diseases, ranging from autoimmune disorders and infectious diseases to fibrosis and cancer. However, TGFβ is always produced as an inactive complex that must be activated to enable binding to its receptor and subsequent function. Recent evidence highlights a crucial role for members of the integrin receptor family in controlling the activation of TGFβ. These pathways are important in human health and disease, and new insights into the biochemical mechanisms that allow integrins to control TGFβ activation could prove useful in the design of therapeutics. © 2010 Elsevier Ltd.
AB - Transforming growth factor beta (TGFβ) controls numerous cellular responses, including proliferation, differentiation, apoptosis and migration. This cytokine is produced by many different cell types and has been implicated in the pathogenesis of many diseases, ranging from autoimmune disorders and infectious diseases to fibrosis and cancer. However, TGFβ is always produced as an inactive complex that must be activated to enable binding to its receptor and subsequent function. Recent evidence highlights a crucial role for members of the integrin receptor family in controlling the activation of TGFβ. These pathways are important in human health and disease, and new insights into the biochemical mechanisms that allow integrins to control TGFβ activation could prove useful in the design of therapeutics. © 2010 Elsevier Ltd.
U2 - 10.1016/j.tibs.2010.08.002
DO - 10.1016/j.tibs.2010.08.002
M3 - Article
C2 - 20870411
SN - 0968-0004
VL - 36
SP - 47
EP - 54
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 1
ER -
