Th1-Th2: reliable paradigm or dangerous dogma?

J E Allen, R M Maizels

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The identification of crossregulating T helper (Th) cells has revolutionized current understanding of the immune response to infection. While paying tribute to this revolution. Judith Allen and Rick Maizels argue that the paradigm can be dangerously oversimplified and that the interaction between host and pathogen cannot always be addressed in the context of Th1 and Th2 cells.

    Original languageEnglish
    Pages (from-to)387-392
    Number of pages6
    JournalImmunology Today
    Volume18
    Issue number8
    Publication statusPublished - Aug 1997

    Keywords

    • T-CELL SUBSET
    • INTERFERON-GAMMA
    • LEISHMANIA-MAJOR
    • CUTANEOUS LEISHMANIASIS
    • PROTECTIVE IMMUNITY
    • VISCERAL LEISHMANIASIS
    • MONOCLONAL-ANTIBODY
    • PLASMODIUM-CHABAUDI
    • DEPENDENT MECHANISM
    • SCHISTOSOMA-MANSONI

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