The 2 Faces of JNK Signaling in Cancer

Cathy Tournier

doi:10.1177/1947601913486349

The 2 Faces of JNK Signaling in Cancer

Research output: Contribution to journal › Article › peer-review

Abstract

c-Jun NH2-terminal kinase (JNK) was discovered almost 20 years ago as the protein kinase responsible for phosphorylating c-Jun at Ser-63 and Ser-73. These sites had previously been demonstrated to be essential for the stimulation of c-Jun activity and for cooperation with Ha-ras in oncogenic transformation. This led to the idea that JNK was a positive regulator of cellular transformation. However, the analysis of jnk gene deletion in various mouse models of cancer has produced conflicting findings, with some studies supporting the pro-oncogenic function of JNK and others providing evidence that JNK acts as a tumor suppressor. This review will discuss how these unexpected findings have increased our understanding of the role of JNK signaling in cancer and have provided a source of new working hypotheses. © The Author(s) 2013.

Original language	English
Pages (from-to)	397-400
Number of pages	3
Journal	Genes and Cancer
Volume	4
Issue number	9-10
DOIs	https://doi.org/10.1177/1947601913486349
Publication status	Published - Sept 2013

Keywords

c-Jun
cancer
JNK
MAPK
MKK
Ras

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1947601913486349

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title = "The 2 Faces of JNK Signaling in Cancer",

abstract = "c-Jun NH2-terminal kinase (JNK) was discovered almost 20 years ago as the protein kinase responsible for phosphorylating c-Jun at Ser-63 and Ser-73. These sites had previously been demonstrated to be essential for the stimulation of c-Jun activity and for cooperation with Ha-ras in oncogenic transformation. This led to the idea that JNK was a positive regulator of cellular transformation. However, the analysis of jnk gene deletion in various mouse models of cancer has produced conflicting findings, with some studies supporting the pro-oncogenic function of JNK and others providing evidence that JNK acts as a tumor suppressor. This review will discuss how these unexpected findings have increased our understanding of the role of JNK signaling in cancer and have provided a source of new working hypotheses. {\textcopyright} The Author(s) 2013.",

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doi = "10.1177/1947601913486349",

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journal = "Genes and Cancer",

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T1 - The 2 Faces of JNK Signaling in Cancer

AU - Tournier, Cathy

PY - 2013/9

Y1 - 2013/9

N2 - c-Jun NH2-terminal kinase (JNK) was discovered almost 20 years ago as the protein kinase responsible for phosphorylating c-Jun at Ser-63 and Ser-73. These sites had previously been demonstrated to be essential for the stimulation of c-Jun activity and for cooperation with Ha-ras in oncogenic transformation. This led to the idea that JNK was a positive regulator of cellular transformation. However, the analysis of jnk gene deletion in various mouse models of cancer has produced conflicting findings, with some studies supporting the pro-oncogenic function of JNK and others providing evidence that JNK acts as a tumor suppressor. This review will discuss how these unexpected findings have increased our understanding of the role of JNK signaling in cancer and have provided a source of new working hypotheses. © The Author(s) 2013.

AB - c-Jun NH2-terminal kinase (JNK) was discovered almost 20 years ago as the protein kinase responsible for phosphorylating c-Jun at Ser-63 and Ser-73. These sites had previously been demonstrated to be essential for the stimulation of c-Jun activity and for cooperation with Ha-ras in oncogenic transformation. This led to the idea that JNK was a positive regulator of cellular transformation. However, the analysis of jnk gene deletion in various mouse models of cancer has produced conflicting findings, with some studies supporting the pro-oncogenic function of JNK and others providing evidence that JNK acts as a tumor suppressor. This review will discuss how these unexpected findings have increased our understanding of the role of JNK signaling in cancer and have provided a source of new working hypotheses. © The Author(s) 2013.

KW - c-Jun

KW - cancer

KW - JNK

KW - MAPK

KW - MKK

KW - Ras

U2 - 10.1177/1947601913486349

DO - 10.1177/1947601913486349

M3 - Article

C2 - 24349637

SN - 1947-6019

VL - 4

SP - 397

EP - 400

JO - Genes and Cancer

JF - Genes and Cancer

IS - 9-10

ER -

The 2 Faces of JNK Signaling in Cancer

Abstract

Keywords

UN SDGs

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