The 2 Faces of JNK Signaling in Cancer

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    c-Jun NH2-terminal kinase (JNK) was discovered almost 20 years ago as the protein kinase responsible for phosphorylating c-Jun at Ser-63 and Ser-73. These sites had previously been demonstrated to be essential for the stimulation of c-Jun activity and for cooperation with Ha-ras in oncogenic transformation. This led to the idea that JNK was a positive regulator of cellular transformation. However, the analysis of jnk gene deletion in various mouse models of cancer has produced conflicting findings, with some studies supporting the pro-oncogenic function of JNK and others providing evidence that JNK acts as a tumor suppressor. This review will discuss how these unexpected findings have increased our understanding of the role of JNK signaling in cancer and have provided a source of new working hypotheses. © The Author(s) 2013.
    Original languageEnglish
    Pages (from-to)397-400
    Number of pages3
    JournalGenes and Cancer
    Issue number9-10
    Publication statusPublished - Sept 2013


    • c-Jun
    • cancer
    • JNK
    • MAPK
    • MKK
    • Ras


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