The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs

Sizheng Zhao; Stephanie R Harrison; Ben Thompson; Max Yates; Joe Eddison; Antoni  Chan; Nick Clarke; Nadia Corp; Charlotte Davis; Lambert Felix; Kalveer Flora; William J Gregory; Gareth T Jones; Christopher A Lamb; Helena Marzo-Ortega; Daniel J. Murphy; Harry Petrushkin; Virinderjit      Sandhu; Raj Sengupta; Stefan Siebert; Danielle A van der Windt; Dale Webb; Zenas Yiu; Karl Gaffney

doi:10.1093/rheumatology/keaf089

The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs

Sizheng Zhao^*
, Stephanie R Harrison
, Ben Thompson
, Max Yates
, Joe Eddison
, Antoni Chan
, Nick Clarke
, Nadia Corp
, Charlotte Davis
, Lambert Felix
, Kalveer Flora
, William J Gregory
, Gareth T Jones
, Christopher A Lamb
, Helena Marzo-Ortega
, Daniel J. Murphy
, Harry Petrushkin
, Virinderjit Sandhu
, Raj Sengupta
, Stefan Siebert

Danielle A van der Windt, Dale Webb, Zenas Yiu, Karl Gaffney

^*Corresponding author for this work

Division of Musculoskeletal & Dermatological Sciences (L5)

Newcastle-upon-Tyne Hospitals NHS Foundation Trust
Norfolk & Norwich University Hospital NHS Foundation Trust
Royal Berkshire NHS Foundation Trust
University of Keele
Leeds Teaching Hospitals NHS Trust
London North West Healthcare NHS Trust
Royal Devon & Exeter Nhs Foundation Trust (Applica
Moorfields Eye Hospital NHS Foundation Trust
St George's University Hospitals NHS Foundation Trust
Royal United Hospital Bath NHS Trust
University of Glasgow
National Axial Spondyloarthritis Society

Research output: Contribution to journal › Article › peer-review

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Original language	English
Article number	keaf089
Journal	Rheumatology
Early online date	9 Apr 2025
DOIs	https://doi.org/10.1093/rheumatology/keaf089
Publication status	Published - 9 Apr 2025

Keywords

axSpA
ankylosing spondylitis
biologics
targeted synthetic DMARDs
treatment
management
guidline
recommendations
extra-musculoskeletal maninfestations
uveitis
psoriasis
inflammatory bowel disease

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10.1093/rheumatology/keaf089

axSpA guideline 2025 full R2_cleanAccepted author manuscript, 172 KBLicence: CC BY

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NIHR Manchester Biomedical Research Centre
Bruce, I. (PI), Lord, G. (CoI), Lennon, R. (CoI), Black, G. (CoI), Wedge, D. (CoI), Morris, A. (CoI), Hussell, T. (CoI), Sharrocks, A. (CoI), Stivaros, S. (CoI), Buch, M. (CoI), Gough, J. (CoI), Kostarelos, K. (CoI), Thistlethwaite, F. (CoI), Kadler, K. (CoI), Barton, A. (CoI), Hyrich, K. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI), Vestbo, J. (CoI), Simpson, A. (CoI), Singh, S. (CoI), Smith, J. (CoI), Felton, T. (CoI), Murray, C. (CoI), Griffiths, C. (CoI), Cullum, N. (CoI), Rhodes, L. (CoI), Warren, R. (CoI), Paus, R. (CoI), Dumville, J. (CoI), Viros Usandizaga, A. (CoI), Keavney, B. (CoI), Tomaszewski, M. (CoI), Allan, S. (CoI), Body, R. (CoI), Cartwright, E. (CoI), Heagerty, A. (CoI), Kalra, P. (CoI), Miller, C. (CoI), Rutter, M. (CoI), Smith, C. (CoI), Trafford, A. (CoI), Evans, D. (CoI), Davidson, E. (CoI), Crosbie, P. (CoI), Harvie, M. (CoI), Howell, S. (CoI), Renehan, A. (CoI), Dive, C. (CoI), Blackhall, F. (CoI), Landers, D. (CoI), Krebs, M. (CoI), Cook, N. (CoI), Clarke, R. (CoI), Taylor, S. (CoI), Jorgensen, C. (CoI), Lorigan, P. (CoI), Jayson, G. (CoI), Valle, J. (CoI), Mccabe, M. (CoI), Armstrong, A. (CoI), Freitas, A. (CoI), Illidge, T. (CoI), Choudhury, A. (CoI), Hoskin, P. (CoI), West, C. (CoI), Van Herk, M. (CoI), Faivre-Finn, C. (CoI), Bristow, R. (CoI), Kirkby, K. (CoI), Birtle, A. (CoI), Mackay, R. (CoI), Radford, J. (CoI), Linton, K. (CoI), Higham, C. (CoI), Munro, K. (CoI), Plack, C. (CoI), Arden Armitage, C. (CoI), Bruce, I. (CoI), Moore, D. (CoI), Saunders, G. (CoI), Stone, M. (CoI), Haddock, G. (CoI), Lewis, S. (CoI), Elliott, R. (CoI), Green, J. (CoI), Lovell, K. (CoI), Morrison, A. (CoI), Shaw, J. (CoI), Bucci, S. (CoI), Ainsworth, J. (CoI), Webb, R. (CoI), Newman, W. (CoI), Banka, S. (CoI), Clayton-Smith, J. (CoI), Payne, K. (CoI), Moldovan, R. (CoI), Wynn, R. (CoI) & Jones, S. (CoI)
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Project: Research
Centre for Epidemiology Versus Arthritis.
Dixon, W. (PI), Bruce, I. (CoI), Felson, D. (CoI), Hyrich, K. (CoI), Lunt, M. (CoI), Mcbeth, J. (CoI), Mcdonagh, J. (CoI), O'Neill, T. (CoI), Sergeant, J. (CoI), Verstappen, S. (CoI) & Serafimova, I. (Support team)
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Project: Research

Cite this

Zhao, S., Harrison, S. R., Thompson, B., Yates, M., Eddison, J., Chan, A., Clarke, N., Corp, N., Davis , C., Felix, L., Flora, K., Gregory, W. J., Jones, G. T., Lamb, C. A., Marzo-Ortega, H., Murphy, D. J., Petrushkin, H., Sandhu, V., Sengupta, R., ... Gaffney, K. (2025). The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs. Rheumatology, Article keaf089. https://doi.org/10.1093/rheumatology/keaf089

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title = "The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs",

keywords = "axSpA, ankylosing spondylitis, biologics, targeted synthetic DMARDs, treatment, management, guidline, recommendations, extra-musculoskeletal maninfestations, uveitis, psoriasis, inflammatory bowel disease",

author = "Sizheng Zhao and Harrison, \{Stephanie R\} and Ben Thompson and Max Yates and Joe Eddison and Antoni Chan and Nick Clarke and Nadia Corp and Charlotte Davis and Lambert Felix and Kalveer Flora and Gregory, \{William J\} and Jones, \{Gareth T\} and Lamb, \{Christopher A\} and Helena Marzo-Ortega and Murphy, \{Daniel J.\} and Harry Petrushkin and Virinderjit Sandhu and Raj Sengupta and Stefan Siebert and \{van der Windt\}, \{Danielle A\} and Dale Webb and Zenas Yiu and Karl Gaffney",

year = "2025",

month = apr,

day = "9",

doi = "10.1093/rheumatology/keaf089",

language = "English",

journal = "Rheumatology",

issn = "1462-0324",

publisher = "Oxford University Press",

}

Zhao, S, Harrison, SR, Thompson, B, Yates, M, Eddison, J, Chan, A, Clarke, N, Corp, N, Davis , C, Felix, L, Flora, K, Gregory, WJ, Jones, GT, Lamb, CA, Marzo-Ortega, H, Murphy, DJ, Petrushkin, H, Sandhu, V, Sengupta, R, Siebert, S, van der Windt, DA, Webb, D, Yiu, Z & Gaffney, K 2025, 'The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs', Rheumatology. https://doi.org/10.1093/rheumatology/keaf089

TY - JOUR

T1 - The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs

AU - Zhao, Sizheng

AU - Harrison, Stephanie R

AU - Thompson, Ben

AU - Yates, Max

AU - Eddison, Joe

AU - Chan, Antoni

AU - Clarke, Nick

AU - Corp, Nadia

AU - Davis , Charlotte

AU - Felix, Lambert

AU - Flora, Kalveer

AU - Gregory, William J

AU - Jones, Gareth T

AU - Lamb, Christopher A

AU - Marzo-Ortega, Helena

AU - Murphy, Daniel J.

AU - Petrushkin, Harry

AU - Sandhu, Virinderjit

AU - Sengupta, Raj

AU - Siebert, Stefan

AU - van der Windt, Danielle A

AU - Webb, Dale

AU - Yiu, Zenas

AU - Gaffney, Karl

PY - 2025/4/9

Y1 - 2025/4/9

KW - axSpA

KW - ankylosing spondylitis

KW - biologics

KW - targeted synthetic DMARDs

KW - treatment

KW - management

KW - guidline

KW - recommendations

KW - extra-musculoskeletal maninfestations

KW - uveitis

KW - psoriasis

KW - inflammatory bowel disease

U2 - 10.1093/rheumatology/keaf089

DO - 10.1093/rheumatology/keaf089

M3 - Article

C2 - 40199504

SN - 1462-0324

JO - Rheumatology

JF - Rheumatology

M1 - keaf089

ER -

The 2025 British Society for Rheumatology guideline for the treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs

Keywords

Access to Document

Projects

NIHR Manchester Biomedical Research Centre

Centre for Epidemiology Versus Arthritis.

Cite this