The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.

Ruta Sahasrabudhe; Ana Estrada; Paul Lott; Lynn Martin; Guadalupe Polanco Echeverry; Alejandro Velez; Gila Neta; Meiko Takahasi; Vladimir Saenko; Norisato Mitsutake; Emma Jaeguer; Carlos Simon Duque; Alejandro Rios; Mabel Bohorquez; Rodrigo Prieto; Angel Criollo; Magdalena Echeverry; Ian Tomlinson; Luis G Carvajal Carmona; Michiko Matsuse; Mitsuyoshi Hirokawa; Eijun Nishihara; Keitaro Matsuo; Fumihiko Matsuda; Huw Thomas; Eamonn Maher; Gareth Evans; Lisa Walker; Dorothy Halliday; Anneke Lucassen; Joan Paterson; Shirley Hodgson; Tessa Homfray; Lucy Side; Louise Izatt; Alan Donaldson; Susan Tomkins; Patrick Morrison; Carole Brewer; Alex Henderson; Rosemarie Davidson; Victoria Murday; Jaqueline Cook; Neva Haites; Timothy Bishop; Eamonn Sheridan; Andrew Green; Christopher Marks; Sue Carpenter; Mary Broughton; Lynn Greenhalge; Mohnish Suri; Laura Moss; Christopher Scrase; Andrew Goodman; Radu Mihai; James Gildersleve; Catherine Lemon; Antony Robinson; Caroline Brammer; Georgina Gerrard; Hisham Mehanna; Matthew Beasley; Hosahalli K Mohan; Sue Clarke; Kate Goodchild; Jonathan Wadsley; Abdel Hamid; Danielle Power; Elena Macias; Jerry Sharp; Andrew Coatsworth; Hamish Courtney; Stephen Whitaker; Katie KatieWood; James McCaul; Christopher Ashford; Tom Roques; Craig Martin; Vivienne Loo; Jennifer Marshall; Amy Roy; Joanna Simpson; Nick Rowell; Edward Babu; Narayanan Srihari; Simon Ellenbogen; Paul Ryan; Arshad Jamil; Terri P McVeigh; Michael J Kerin; Aoife J Lowery

doi:10.1530/ERC-15-0081

The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.

Ruta Sahasrabudhe, Ana Estrada, Paul Lott, Lynn Martin, Guadalupe Polanco Echeverry, Alejandro Velez, Gila Neta, Meiko Takahasi, Vladimir Saenko, Norisato Mitsutake, Emma Jaeguer, Carlos Simon Duque, Alejandro Rios, Mabel Bohorquez, Rodrigo Prieto, Angel Criollo, Magdalena Echeverry, Ian Tomlinson, Luis G Carvajal Carmona, Michiko Matsuse (Collaborator)Mitsuyoshi Hirokawa (Collaborator), Eijun Nishihara (Collaborator), Keitaro Matsuo (Collaborator), Fumihiko Matsuda (Collaborator), Huw Thomas (Collaborator), Eamonn Maher (Collaborator), Gareth Evans (Collaborator), Lisa Walker (Collaborator), Dorothy Halliday (Collaborator), Anneke Lucassen (Collaborator), Joan Paterson (Collaborator), Shirley Hodgson (Collaborator), Tessa Homfray (Collaborator), Lucy Side (Collaborator), Louise Izatt (Collaborator), Alan Donaldson (Collaborator), Susan Tomkins (Collaborator), Patrick Morrison (Collaborator), Carole Brewer (Collaborator), Alex Henderson (Collaborator), Rosemarie Davidson (Collaborator), Victoria Murday (Collaborator), Jaqueline Cook (Collaborator), Neva Haites (Collaborator), Timothy Bishop (Collaborator), Eamonn Sheridan (Collaborator), Andrew Green (Collaborator), Christopher Marks (Collaborator), Sue Carpenter (Collaborator), Mary Broughton (Collaborator), Lynn Greenhalge (Collaborator), Mohnish Suri (Collaborator), Laura Moss (Collaborator), Christopher Scrase (Collaborator), Andrew Goodman (Collaborator), Radu Mihai (Collaborator), James Gildersleve (Collaborator), Catherine Lemon (Collaborator), Antony Robinson (Collaborator), Caroline Brammer (Collaborator), Georgina Gerrard (Collaborator), Hisham Mehanna (Collaborator), Matthew Beasley (Collaborator), Hosahalli K Mohan (Collaborator), Sue Clarke (Collaborator), Kate Goodchild (Collaborator), Jonathan Wadsley (Collaborator), Abdel Hamid (Collaborator), Danielle Power (Collaborator), Elena Macias (Collaborator), Jerry Sharp (Collaborator), Andrew Coatsworth (Collaborator), Hamish Courtney (Collaborator), Stephen Whitaker (Collaborator), Katie KatieWood (Collaborator), James McCaul (Collaborator), Christopher Ashford (Collaborator), Tom Roques (Collaborator), Craig Martin (Collaborator), Vivienne Loo (Collaborator), Jennifer Marshall (Collaborator), Amy Roy (Collaborator), Joanna Simpson (Collaborator), Nick Rowell (Collaborator), Edward Babu (Collaborator), Narayanan Srihari (Collaborator), Simon Ellenbogen (Collaborator), Paul Ryan (Collaborator), Arshad Jamil (Collaborator), Terri P McVeigh (Collaborator), Michael J Kerin (Collaborator), Aoife J Lowery (Collaborator)

University College Dublin

Research output: Contribution to journal › Article › peer-review

Abstract

The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls. We detected significant associations between rs6983267G and TC in the British Isles (odds ratio (OR)=1.19, 95% CI: 1.11-1.27, P=4.03×10(-7)), Japan (OR=1.20, 95% CI: 1.03-1.41, P=0.022) and a borderline significant association of similar effect direction and size in Colombia (OR=1.19, 95% CI: 0.99-1.44, P=0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5484 cases and 12 594 controls, confirmed the association between rs6983267G and TC (P=1.23×10(-7), OR=1.13, 95% CI: 1.08-1.18). Our results therefore support the notion that rs6983267G is a bona fide TC risk variant that increases the risk of disease by ∼13%.

Original language	English
Journal	Endocrine-related cancer
Volume	22
Issue number	5
DOIs	https://doi.org/10.1530/ERC-15-0081
Publication status	Published - Oct 2015

Keywords

8q24
genetic susceptibility
rs6983267G
thyroid cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1530/ERC-15-0081

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Sahasrabudhe, R., Estrada, A., Lott, P., Martin, L., Polanco Echeverry, G., Velez, A., Neta, G., Takahasi, M., Saenko, V., Mitsutake, N., Jaeguer, E., Duque, C. S., Rios, A., Bohorquez, M., Prieto, R., Criollo, A., Echeverry, M., Tomlinson, I., Carmona, L. G. C., ... Lowery, A. J. (2015). The 8q24 rs6983267G variant is associated with increased thyroid cancer risk. Endocrine-related cancer, 22(5). https://doi.org/10.1530/ERC-15-0081

@article{0af29340c12b4b52b00640693de81e19,

title = "The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.",

abstract = "The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls. We detected significant associations between rs6983267G and TC in the British Isles (odds ratio (OR)=1.19, 95\% CI: 1.11-1.27, P=4.03×10(-7)), Japan (OR=1.20, 95\% CI: 1.03-1.41, P=0.022) and a borderline significant association of similar effect direction and size in Colombia (OR=1.19, 95\% CI: 0.99-1.44, P=0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5484 cases and 12 594 controls, confirmed the association between rs6983267G and TC (P=1.23×10(-7), OR=1.13, 95\% CI: 1.08-1.18). Our results therefore support the notion that rs6983267G is a bona fide TC risk variant that increases the risk of disease by ∼13\%.",

keywords = "8q24, genetic susceptibility, rs6983267G, thyroid cancer",

author = "Ruta Sahasrabudhe and Ana Estrada and Paul Lott and Lynn Martin and \{Polanco Echeverry\}, Guadalupe and Alejandro Velez and Gila Neta and Meiko Takahasi and Vladimir Saenko and Norisato Mitsutake and Emma Jaeguer and Duque, \{Carlos Simon\} and Alejandro Rios and Mabel Bohorquez and Rodrigo Prieto and Angel Criollo and Magdalena Echeverry and Ian Tomlinson and Carmona, \{Luis G Carvajal\} and Michiko Matsuse and Mitsuyoshi Hirokawa and Eijun Nishihara and Keitaro Matsuo and Fumihiko Matsuda and Huw Thomas and Eamonn Maher and Gareth Evans and Lisa Walker and Dorothy Halliday and Anneke Lucassen and Joan Paterson and Shirley Hodgson and Tessa Homfray and Lucy Side and Louise Izatt and Alan Donaldson and Susan Tomkins and Patrick Morrison and Carole Brewer and Alex Henderson and Rosemarie Davidson and Victoria Murday and Jaqueline Cook and Neva Haites and Timothy Bishop and Eamonn Sheridan and Andrew Green and Christopher Marks and Sue Carpenter and Mary Broughton and Lynn Greenhalge and Mohnish Suri and Laura Moss and Christopher Scrase and Andrew Goodman and Radu Mihai and James Gildersleve and Catherine Lemon and Antony Robinson and Caroline Brammer and Georgina Gerrard and Hisham Mehanna and Matthew Beasley and Mohan, \{Hosahalli K\} and Sue Clarke and Kate Goodchild and Jonathan Wadsley and Abdel Hamid and Danielle Power and Elena Macias and Jerry Sharp and Andrew Coatsworth and Hamish Courtney and Stephen Whitaker and Katie KatieWood and James McCaul and Christopher Ashford and Tom Roques and Craig Martin and Vivienne Loo and Jennifer Marshall and Amy Roy and Joanna Simpson and Nick Rowell and Edward Babu and Narayanan Srihari and Simon Ellenbogen and Paul Ryan and Arshad Jamil and McVeigh, \{Terri P\} and Kerin, \{Michael J\} and Lowery, \{Aoife J\}",

note = "075491/Z/04, Wellcome Trust, United KingdomK12 CA138464, NCI NIH HHS, United StatesK12CA138464, NCI NIH HHS, United StatesP30 AG043097, NIA NIH HHS, United StatesP30AG043097, NIA NIH HHS, United States, Cancer Research UK, United Kingdom",

year = "2015",

month = oct,

doi = "10.1530/ERC-15-0081",

language = "English",

volume = "22",

journal = "Endocrine-related cancer",

issn = "1479-6821",

publisher = "BioScientifica",

number = "5",

}

Sahasrabudhe, R, Estrada, A, Lott, P, Martin, L, Polanco Echeverry, G, Velez, A, Neta, G, Takahasi, M, Saenko, V, Mitsutake, N, Jaeguer, E, Duque, CS, Rios, A, Bohorquez, M, Prieto, R, Criollo, A, Echeverry, M, Tomlinson, I, Carmona, LGC, Matsuse, M, Hirokawa, M, Nishihara, E, Matsuo, K, Matsuda, F, Thomas, H, Maher, E, Evans, G, Walker, L, Halliday, D, Lucassen, A, Paterson, J, Hodgson, S, Homfray, T, Side, L, Izatt, L, Donaldson, A, Tomkins, S, Morrison, P, Brewer, C, Henderson, A, Davidson, R, Murday, V, Cook, J, Haites, N, Bishop, T, Sheridan, E, Green, A, Marks, C, Carpenter, S, Broughton, M, Greenhalge, L, Suri, M, Moss, L, Scrase, C, Goodman, A, Mihai, R, Gildersleve, J, Lemon, C, Robinson, A, Brammer, C, Gerrard, G, Mehanna, H, Beasley, M, Mohan, HK, Clarke, S, Goodchild, K, Wadsley, J, Hamid, A, Power, D, Macias, E, Sharp, J, Coatsworth, A, Courtney, H, Whitaker, S, KatieWood, K, McCaul, J, Ashford, C, Roques, T, Martin, C, Loo, V, Marshall, J, Roy, A, Simpson, J, Rowell, N, Babu, E, Srihari, N, Ellenbogen, S, Ryan, P, Jamil, A, McVeigh, TP, Kerin, MJ & Lowery, AJ 2015, 'The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.', Endocrine-related cancer, vol. 22, no. 5. https://doi.org/10.1530/ERC-15-0081

TY - JOUR

T1 - The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.

AU - Sahasrabudhe, Ruta

AU - Estrada, Ana

AU - Lott, Paul

AU - Martin, Lynn

AU - Polanco Echeverry, Guadalupe

AU - Velez, Alejandro

AU - Neta, Gila

AU - Takahasi, Meiko

AU - Saenko, Vladimir

AU - Mitsutake, Norisato

AU - Jaeguer, Emma

AU - Duque, Carlos Simon

AU - Rios, Alejandro

AU - Bohorquez, Mabel

AU - Prieto, Rodrigo

AU - Criollo, Angel

AU - Echeverry, Magdalena

AU - Tomlinson, Ian

AU - Carmona, Luis G Carvajal

A2 - Matsuse, Michiko

A2 - Hirokawa, Mitsuyoshi

A2 - Nishihara, Eijun

A2 - Matsuo, Keitaro

A2 - Matsuda, Fumihiko

A2 - Thomas, Huw

A2 - Maher, Eamonn

A2 - Evans, Gareth

A2 - Walker, Lisa

A2 - Halliday, Dorothy

A2 - Lucassen, Anneke

A2 - Paterson, Joan

A2 - Hodgson, Shirley

A2 - Homfray, Tessa

A2 - Side, Lucy

A2 - Izatt, Louise

A2 - Donaldson, Alan

A2 - Tomkins, Susan

A2 - Morrison, Patrick

A2 - Brewer, Carole

A2 - Henderson, Alex

A2 - Davidson, Rosemarie

A2 - Murday, Victoria

A2 - Cook, Jaqueline

A2 - Haites, Neva

A2 - Bishop, Timothy

A2 - Sheridan, Eamonn

A2 - Green, Andrew

A2 - Marks, Christopher

A2 - Carpenter, Sue

A2 - Broughton, Mary

A2 - Greenhalge, Lynn

A2 - Suri, Mohnish

A2 - Moss, Laura

A2 - Scrase, Christopher

A2 - Goodman, Andrew

A2 - Mihai, Radu

A2 - Gildersleve, James

A2 - Lemon, Catherine

A2 - Robinson, Antony

A2 - Brammer, Caroline

A2 - Gerrard, Georgina

A2 - Mehanna, Hisham

A2 - Beasley, Matthew

A2 - Mohan, Hosahalli K

A2 - Clarke, Sue

A2 - Goodchild, Kate

A2 - Wadsley, Jonathan

A2 - Hamid, Abdel

A2 - Power, Danielle

A2 - Macias, Elena

A2 - Sharp, Jerry

A2 - Coatsworth, Andrew

A2 - Courtney, Hamish

A2 - Whitaker, Stephen

A2 - KatieWood, Katie

A2 - McCaul, James

A2 - Ashford, Christopher

A2 - Roques, Tom

A2 - Martin, Craig

A2 - Loo, Vivienne

A2 - Marshall, Jennifer

A2 - Roy, Amy

A2 - Simpson, Joanna

A2 - Rowell, Nick

A2 - Babu, Edward

A2 - Srihari, Narayanan

A2 - Ellenbogen, Simon

A2 - Ryan, Paul

A2 - Jamil, Arshad

A2 - McVeigh, Terri P

A2 - Kerin, Michael J

A2 - Lowery, Aoife J

N1 - 075491/Z/04, Wellcome Trust, United KingdomK12 CA138464, NCI NIH HHS, United StatesK12CA138464, NCI NIH HHS, United StatesP30 AG043097, NIA NIH HHS, United StatesP30AG043097, NIA NIH HHS, United States, Cancer Research UK, United Kingdom

PY - 2015/10

Y1 - 2015/10

N2 - The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls. We detected significant associations between rs6983267G and TC in the British Isles (odds ratio (OR)=1.19, 95% CI: 1.11-1.27, P=4.03×10(-7)), Japan (OR=1.20, 95% CI: 1.03-1.41, P=0.022) and a borderline significant association of similar effect direction and size in Colombia (OR=1.19, 95% CI: 0.99-1.44, P=0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5484 cases and 12 594 controls, confirmed the association between rs6983267G and TC (P=1.23×10(-7), OR=1.13, 95% CI: 1.08-1.18). Our results therefore support the notion that rs6983267G is a bona fide TC risk variant that increases the risk of disease by ∼13%.

AB - The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls. We detected significant associations between rs6983267G and TC in the British Isles (odds ratio (OR)=1.19, 95% CI: 1.11-1.27, P=4.03×10(-7)), Japan (OR=1.20, 95% CI: 1.03-1.41, P=0.022) and a borderline significant association of similar effect direction and size in Colombia (OR=1.19, 95% CI: 0.99-1.44, P=0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5484 cases and 12 594 controls, confirmed the association between rs6983267G and TC (P=1.23×10(-7), OR=1.13, 95% CI: 1.08-1.18). Our results therefore support the notion that rs6983267G is a bona fide TC risk variant that increases the risk of disease by ∼13%.

KW - 8q24

KW - genetic susceptibility

KW - rs6983267G

KW - thyroid cancer

U2 - 10.1530/ERC-15-0081

DO - 10.1530/ERC-15-0081

M3 - Article

C2 - 26290501

SN - 1479-6821

VL - 22

JO - Endocrine-related cancer

JF - Endocrine-related cancer

IS - 5

ER -

The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.

Abstract

Keywords

UN SDGs

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