The abundance of mRNA for dopamine D2 receptor isoforms in brain tissue from controls and schizophrenics

D A Roberts, D Balderson, S M Pickering-Brown, J F Deakin, F Owen

Research output: Contribution to journalArticlepeer-review

Abstract

The possibility that schizophrenia is associated with a differential expression, in the brain, of the short and long isoforms of the dopamine D2 receptor has been investigated by assessing the abundance of mRNA for each of the isoforms. Using a quantitative RNA-PCR technique, increased mRNA for both isoforms of the D2 receptor were observed in some brain regions, with no differential distribution between the isoforms in the schizophrenics compared to controls.

Original languageEnglish
Pages (from-to)173-5
Number of pages3
JournalMolecular Brain Research
Volume25
Issue number1-2
Publication statusPublished - Aug 1994

Keywords

  • Base Sequence
  • Brain Chemistry
  • Humans
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA, Messenger
  • Receptors, Dopamine D2
  • Reference Values
  • Schizophrenia
  • Journal Article
  • Research Support, Non-U.S. Gov't

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