The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development

A. S. Tucker; D. J. Headon; J. M. Courtney; P. Overbeek; P. T. Sharpe

doi:10.1016/j.ydbio.2003.12.019

The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development

A. S. Tucker, D. J. Headon, J. M. Courtney, P. Overbeek, P. T. Sharpe

Research output: Contribution to journal › Article › peer-review

Abstract

Mutations in members of the ectodysplasin (TNF-related) signalling pathway, EDA, EDAR, and EDARADD in mice and humans produce an ectodermal dysplasia phenotype that includes missing teeth and smaller teeth with reduced cusps. Using the keratin 14 promoter to target expression of an activated form of Edar in transgenic mice, we show that expression of this transgene is able to rescue the tooth phenotype in Tabby (Eda) and Sleek (Edar) mutant mice. High levels of expression of the transgene in wild-type mice result in molar teeth with extra cusps, and in some cases supernumerary teeth, the opposite of the mutant phenotype. The level of activation of Edar thus determines cusp number and tooth number during tooth development. © 2004 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	185-194
Number of pages	9
Journal	Developmental Biology
Volume	268
Issue number	1
DOIs	https://doi.org/10.1016/j.ydbio.2003.12.019
Publication status	Published - 1 Apr 2004

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title = "The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development",

abstract = "Mutations in members of the ectodysplasin (TNF-related) signalling pathway, EDA, EDAR, and EDARADD in mice and humans produce an ectodermal dysplasia phenotype that includes missing teeth and smaller teeth with reduced cusps. Using the keratin 14 promoter to target expression of an activated form of Edar in transgenic mice, we show that expression of this transgene is able to rescue the tooth phenotype in Tabby (Eda) and Sleek (Edar) mutant mice. High levels of expression of the transgene in wild-type mice result in molar teeth with extra cusps, and in some cases supernumerary teeth, the opposite of the mutant phenotype. The level of activation of Edar thus determines cusp number and tooth number during tooth development. {\textcopyright} 2004 Elsevier Inc. All rights reserved.",

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T1 - The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development

AU - Tucker, A. S.

AU - Headon, D. J.

AU - Courtney, J. M.

AU - Overbeek, P.

AU - Sharpe, P. T.

PY - 2004/4/1

Y1 - 2004/4/1

N2 - Mutations in members of the ectodysplasin (TNF-related) signalling pathway, EDA, EDAR, and EDARADD in mice and humans produce an ectodermal dysplasia phenotype that includes missing teeth and smaller teeth with reduced cusps. Using the keratin 14 promoter to target expression of an activated form of Edar in transgenic mice, we show that expression of this transgene is able to rescue the tooth phenotype in Tabby (Eda) and Sleek (Edar) mutant mice. High levels of expression of the transgene in wild-type mice result in molar teeth with extra cusps, and in some cases supernumerary teeth, the opposite of the mutant phenotype. The level of activation of Edar thus determines cusp number and tooth number during tooth development. © 2004 Elsevier Inc. All rights reserved.

AB - Mutations in members of the ectodysplasin (TNF-related) signalling pathway, EDA, EDAR, and EDARADD in mice and humans produce an ectodermal dysplasia phenotype that includes missing teeth and smaller teeth with reduced cusps. Using the keratin 14 promoter to target expression of an activated form of Edar in transgenic mice, we show that expression of this transgene is able to rescue the tooth phenotype in Tabby (Eda) and Sleek (Edar) mutant mice. High levels of expression of the transgene in wild-type mice result in molar teeth with extra cusps, and in some cases supernumerary teeth, the opposite of the mutant phenotype. The level of activation of Edar thus determines cusp number and tooth number during tooth development. © 2004 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.ydbio.2003.12.019

DO - 10.1016/j.ydbio.2003.12.019

M3 - Article

VL - 268

SP - 185

EP - 194

JO - Developmental Biology

JF - Developmental Biology

IS - 1

ER -

The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development

Abstract

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