The antimalarial activity of berberine and some synthetic analogues

N. Silikas, D. L C McCall, D. Sharples, W. M. Watkins, R. D. Waigh, J. Barber

    Research output: Contribution to journalArticlepeer-review


    Berberine chloride and ten synthetic analogues were tested for antimalarial activity and for interaction with DNA. Antimalarial activity was assessed by measurement of inhibition of growth of Plasmodium falciparum in-vitro, using chloroquine-sensitive and -resistant strains. DNA interactions were assessed by UV spectrophotometric studies, thermal denaturation measurements and gel electrophoresis. Four of the compounds including berberine chloride were found to show some interaction with DNA which showed some correlation with antimalarial activity. Berberine is known to inhibit several enzymes, as well as DNA and these results suggest that DNA is not the only site of antimalarial action of these analogues.
    Original languageEnglish
    Pages (from-to)55-58
    Number of pages3
    JournalPharmaceutical Sciences
    Issue number1
    Publication statusPublished - 1996


    Dive into the research topics of 'The antimalarial activity of berberine and some synthetic analogues'. Together they form a unique fingerprint.

    Cite this